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1、萬方數據復旦大學碩士論文後旦大學碩士學位論文學校代碼:10246學號:10211010072嗅球調控快動眼睡眠的分子機制院系:專業(yè):姓名:指導教師:導師小組成員:完成日期:基礎醫(yī)學院藥理學涂治才黃志力教授王毅群講師2013年5月萬方數據復旦大學碩上論文嗅球調控快動眼睡眠的分子機制目錄目錄?????????????????????i縮略詞表???????????????????..ii中文摘要???????????????????..1Abstract..........................................
2、.................:}奢部分:嗅球切除術研究快動眼睡眠異常和抑郁癥因果關系?.???4材料與方法?????????????????..5實驗結果??????????????????11實驗結果圖?????????????????.15討論???????????????????.38小結???????????????????.40第二部分:嗅球通過腺苷A:A受體參與快動眼睡眠的調節(jié)?????.46材料與方法?????????????????.48實驗結果??????????????????53實驗結果圖????????
3、?????????.56i寸論???????????????????.66小結???????????????????.68全文總結???????????????????.69本研究創(chuàng)新點??????????????????70綜述:快動眼睡眠發(fā)生的腦干機制????????????73附錄:在校期間所發(fā)論文和所獲基金???????????.89致謝????????????????????..90萬方數據復旦大學碩士論文5.HIAA5.HTA2AR刪AchCGS21680DADABD2RDRNECDEEGEMGFSTGABAHPLCh以
4、FPHVALCLDTNENREMSleepOB0BX0FTPCAPGPPTRBD縮略詞表5-hydroxyindoleaceticacid5-hydroxytryptamineadenosineA2AreceptorsAdeno.associatedvirusAcetylcholine(2一(4一(2-carboxyethyl)phenylethylamino)··adenosine·-5'-N-·ethyicarboxamide—adenosinedopaminediaminobenzidinedopamineD2receptor
5、sdorsalraphenucleuselectroncapturedetectorelectroencephalogramelectromyogramforcedswimmingtest1/-aminobutyricacidhi曲preformanceliquidvhromatographyhumanizedrenillagreenfluorescentproteinhomovanillicacidlOClIScoeruleuslaterodorsaltegmentalnucleusnorepinephrinenon-rapide
6、yemovementsleepolfactorybulbolfactorybulbectomyopenfieldtestperchloricacidprostaglandinpedunculopontinetegmentalnucleusREMsleepbehaviordisorder5.羥吲哚乙酸5.羥色胺腺苷A2A受體腺相關病毒乙酰膽堿腺苷A2AR激動劑多巴胺二氨基聯苯胺多巴胺D2受體中縫核電子捕獲檢測器腦電圖肌電圖強迫游泳試驗v一氨基丁酸高效液相色譜人源化海腎綠色熒光蛋白高香草酸藍斑核外背側被蓋核去甲腎上腺素非快動眼睡眠嗅球雙
7、側嗅球切除曠場試驗高氯酸前列腺素腳橋被蓋核REM睡眠行為障礙萬方數據復旦大學碩十論文PBSPBTREMSleepRISCSCH58261SDSLDSⅥATMNVLPAGVLPOWTphosphatebufferedsalinephosphatebufferedsalinewithTween20rapideyemovementsleepRNA—inducedsilencingcomplex5-Amino一7一(2-phenylethyl)-2一(2一如ry1)一pyrazolo(4,3一e)一1,2,4-triazolo(1,5一c)
8、pyrimidinesleepdeprivationsublaterodorasltegmentalnucleusslowwaveactivitytuberomammillarynucleusventrolateralperiaqui