graphene cell culture

graphene cell culture

ID:39934847

大小:1.77 MB

頁數(shù):9頁

時間:2019-07-15

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1、Biomaterials32(2011)9374e9382ContentslistsavailableatSciVerseScienceDirectBiomaterialsjournalhomepage:www.elsevier.com/locate/biomaterialsThepromotionofneuritesproutingandoutgrowthofmousehippocampalcellsinculturebygraphenesubstratesa,ca,daa,caaa,cb,cNingLi,XueminZhang,QinS

2、ong,RuigongSu,QiZhang,TaoKong,LiweiLiu,GangJin,a,c,*a,c,*MingliangTang,GuoshengChengaSuzhouInstituteofNano-TechandNano-Bionics,ChineseAcademyofSciences,398RuoshuiRoad,SuzhouIndustrialPark215123,PRChinabInstituteofMechanics,ChineseAcademyofSciences,15BeisihuanWestRoad,Beiji

3、ng,100190,PRChinacGraduateUniversityoftheChineseAcademyofSciences,19AYuquanRoad,Beijing,100049,PRChinadChangchunUniversityofScienceandTechnology,WeixingRoad,Changchun,Jilin,130022,PRChinaarticleinfoabstractArticlehistory:Graphenehasbeendemonstratedinmanybiomedicalapplicati

4、onsanditspotentialsforneuralinter-Received4August2011facing.Emergingconcernsongraphene,asabiomedicalmaterial,areitsbiocompatibilityandhowAccepted19August2011biologicallytargetedtissue/cellsrespondtoit.Relativelyfewstudiesattemptedtoaddresstheinterac-Availableonline8Septemb

5、er2011tionsofgrapheneoritsderivativeswiththetissues/cells,whileveryfewreportsonneuralsystem.Inthisstudy,wetriedtoexplorehowneurites,oneofthekeystructuresforneuralfunctions,areaffectedbyKeywords:grapheneduringthedevelopmentuntilmaturationinamousehippocampalculturemodel.Ther

6、esultsNeuron-favorableCVDgraphenerevealthatgraphenesubstratesexhibitedexcellentbiocompatibility,ascellviabilityandmorphologyGAP-43werenotaffected.Meanwhile,neuritenumbersandaverageneuritelengthongrapheneweresigni?-Neuritesprouting&outgrowthHippocampuscantlyenhancedduring2e

7、7daysaftercellseedingcomparedwithtissueculturepolystyrene(TCPS)substrates.EspeciallyonDay2oftheneuraldevelopmentperiod,graphenesubstratesef?cientlypromotedneuritesproutingandoutgrowthtothemaximalextent.Additionally,expressionofgrowth-associateprotein-43(GAP-43)wasexaminedi

8、nbothgrapheneandTCPSgroups.WesternblotanalysisshowedthatGAP-43expressionwasgreatlyenhance

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