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《current medical research programs》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫。
1、CurrentMedicalResearchPrograms?HypothermicReperfusionafterIschemiaImprovesVentricularMyocyteContractilityandIntracellularCa2+?Dynamics?Anenergy-sparingeffectofhypothermiahasbeendescribed,suchthatloweringthetemperaturemayleadtoincreasesincardiacworkwithoutincreases
2、inenergycost.Wehaverecentlyreportedimprovedmyocardialfunctionwithhypothermiafollowingresuscitationfromcardiacarrest.Inthepresent?investigation,wehypothesizedthatreductionsinreperfusiontemperaturefrom37°C?to?30°C?after10minutesofischemiawouldminimizethedecreasesinm
3、yocytecontractilityandintracellularCa2+transients.?Results:?Hypothermicreperfusionfollowingischemiaimproved?myocytecontractility.?Increasedmyocyte?intracellularCa2+?dynamicsduringhypothermiaaccountedforthegreatercellcontractility.?HypothermiaImprovesVentricularMyo
4、cyteSensitivitytoExtracellular?Ca2+Wehavepreviouslyreportedthathypothermiaminimizestheimpairmentofmyocytecontractilityfollowingischemia.Inthepresent?study,?weinvestigatedthemechanismsaccountingforthesereducedimpairmentsincontractility.Wehypothesizedthathypothermia
5、wouldincreasemyocyte?sensitivity?to?extracellularCa2+?underconditionsofnormalperfusionandfollowingreperfusionafterischemia.?Results:?HypothermiaincreasedmyocytesensitivitytoextracellularCa2+?content,andthisaccountedforgreatercontractility.?Hypothermicreperfusionaf
6、terischemiamaintainedgreaterresponsivenessofmyocytecontractilitytoextracellularCa2+?content,incomparisontonormothermicreperfusion.??Current-BasedImpedanceCompensationOutperformedDuration-BasedTechniqueinDefibrillationEfficacyinaHighImpedancePigModelTransthoracicim
7、pedance(TI)fordefibrillationvarieswidelyinpatientswithamedianvalueofapproximately95-100ohms.Highimpedancepatientsaremoredifficulttodefibrillate.Themoderngenerationofexternaldefibrillatorsthereforeadjustsdefibrillationoutputbasedonpatientimpedancemeasurementpriorto
8、shockdelivery(impedancecompensation).Commercialexternaldefibrillatorsusedifferentimpedancecompensationmethods(ICM).DefibrillatorA(DefA,rectilinearbiphas
