資源描述：
《structural genomics of conserved gene families - rutgers…》由會員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫。
1、StructuralgenomicsofconservedgenefamiliesByRamManiAdvisor:GaetanoT.Montelione,Ph.D.CenterforAdvancedBiotechnologyandMedicine;DepartmentofMolecularBiology&Biochemistry,Rutgers,TheStateUniversityofNewJersey--Piscataway,NJInfulfillmentofrequirementsfortheH
2、enryRutgersScholarsProgramMay2000AcknowledgementsIhavebeenworkinginDr.GaetanoMontelione'slaboratorysinceMay1997,whichmakesthenumberofpersonstothankverylarge.Ifsomeoneisexcludedpleaseforgiveme.MembersofDr.Montelione'slabhavebeentremendouslysupportive.Ron
3、gXiaohastaughtmesomuchduringmyproteinexpressionandpurificationwork.DaphnePalacioshasbeenanexcellentteacherduringmuchofthemolecularbiologyworkofmyCOGproject.Dr.KristinGunsalusprovidedessentialcoordinationduringmyworkwithCOG's,andherproteinexpressionkitha
4、sbeenavaluableresource.Severalothers(e.g.Drs.AlbertChienandParagSahasrabudhe)werealwayswillingtoanswermyquestionsaboutDNAandproteinpreparation.WithouttheworkofAlexandraGardinoandCharlesLu,myworkonCOG0229Swouldnothavebeenpossible.EmilyLywaskindenoughtosh
5、areinmymolecularbiologyworkinCOG0316S.GurmukhSahotahasbeenverygraciousinhelpingmeintimesofneed.Dr.MontelioneandDr.StephenAndersonhavebeenkindenoughtoserveonmythesispresentationcommitteeanddealwithdelaysthatcamewiththecompositionofthisthesis.Bothhaveprov
6、idedvaluableassistanceduringmycomputationalwork.Last,butnotleast,IwouldliketorecognizetheoveralldirectionthatDr.Montelionehasprovidedmeduringallofmyprojects.Hisintelligenceandcreativityandbeenlargemotivatingfactorsformywork.TableofContentsChapter1Introd
7、uctionPage1ExperimentalMethodsComputationalBiology5MolecularBiology10Biochemistry20ResultsandDiscussion30ConclusionandFutureWork41References43Legends45FiguresandTablesunpaginatedChapter2Abstract53Introduction54ExperimentalMethods55ResultsandDiscussion59
8、References66Table70FigureLegends75FiguresunpaginatedPrefacetothethesisThisthesiswaswrittenastwochapters,eachwrittenindependentlyoftheother.ChapteronedescribesworkthatIhavedoneduringinvestigationofthreedomainfamiliesofunknownfunct
