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1、馬兜鈴酸A在中藥飲片及其配方顆粒中的含量分析黃國鑫,倪晨,李一圣,易宇陽,張仲敏,趙學(xué)軍,蘇子仁[第一作者]黃國鑫,研究生,從事中藥新藥開發(fā)與研究,Tel,39356860;Email,hgvxin@gmail.com[通訊作者]:蘇子仁,研究員,從事中藥新藥開發(fā)與研究,Tel,39358517;Email,vip.suziren@gzhtcm.edu.cn。廣州中醫(yī)藥大學(xué)中藥學(xué)院[摘要]目的:對5種馬兜鈴科中藥飲片及配方顆粒(由相應(yīng)批次的中藥飲片制成)所含馬兜鈴酸A進行含量測定,為促進我國中藥配方顆粒事業(yè)發(fā)展提供科學(xué)依據(jù)。方法:采用高效液相色譜法。色譜柱為YMC
2、-PackC18色譜柱(250×4.6mm,5μm);流動相:甲醇(B)-0.05%磷酸溶液(A);檢測波長:250nm;流速:0.8ml·min-1;柱溫:30℃。結(jié)果:5種馬兜鈴科中藥飲片(各3批)中馬兜鈴酸A平均含量分別為:關(guān)木通4.18mg/g,馬兜鈴0.77mg/g,蜜馬兜鈴0.46mg/g,青木香0.86mg/g,尋骨風0.53mg/g;5種中藥配方顆粒(各3批)馬兜鈴酸A平均含量分別為:關(guān)木通1.16mg/g,馬兜鈴0.31mg/g,蜜馬兜鈴0.10mg/g,青木香0.39mg/g,尋骨風0.03mg/g。結(jié)論:本文所建立的方法對多種含馬兜鈴酸A藥材
3、與配方顆粒具有較好的適應(yīng)性,可以用于其含量測定;中藥配方顆粒的制作工藝對中藥飲片的成分有一定影響,有必要建立相關(guān)生產(chǎn)監(jiān)控標準、質(zhì)量控制標準,用來保證中藥配方顆粒的質(zhì)量。關(guān)鍵詞:馬兜鈴酸A;中藥飲片;中藥配方顆粒AssayingofAristolochicAcidAinChineseHerbalPiecesandtheTraditionalChineseMedicineParticleHuangGuoxin,NiChen,LiYisheng,YiYuyang,ZhangZhongmin,ZhaoXuejun,SuZiren*SchoolofTraditionlChi
4、neseMateriaMedica,GuangzhouUniversityofChineseMedicine[Abstract]Objective:ThecontentofaristolochicacidAinthefivekindsofmedicalmaterialsanddispensinggranulesofAristolochiaceaefamilywasdeterminedtoprovidescientificfoundationforpromotingdevelopmentofourtraditionalChinesemedicineparticle.
5、Methods:HPLCmethodwasappliedonYMC-PackC18column(250x4.6mm,5μm)at30℃withmethanol(B)-0.05%phosphoricacid(A)asthemobilephase;detectedwavelengthwasat250nm,andtheflowratewas0.8ml/min.Results:ThecontentofaristolochicacidAinthefivekindsofmedicalmaterials,i.e.Akebiastem,DutchmanspipeFruit,hon
6、eyedDutchmanspipeFruit,RadixAristolochiaeandDatchmanspipeHerbwas4.18mg/g,0.77mg/g,0.46mg/g,0.86mg/g,0.53mg/grespectively.ThecontentofaristolochicacidAinthefivekindsofdispensinggranuleswas1.16mg/gforAkebiastem,0.31mg/gforDutchmanspipeFruit,0.10mg/gforhoneyedDutchmanspipeFruit,0.39mg/gf
7、orRadixAristolochiaeand0.03mg/gforDatchmanspipeHerbrespectively.Conclusion:ThemethodestablishedinthispaperhasrelativeadaptabilityforvariouskindsofmedicalmaterialsanddispensinggranulescontainingaristolochicacidA.Itcanbeusedforcontentdetermination.TheproductionprocessoftraditionalChines
8、emedi