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1、VEGF和PEDF在實驗性大鼠角膜新生血管組織中的動態(tài)表達眼科新進展2006年8月第26卷第8期RecAdvOphthalmolVo1.26No.8August2006?573?作者簡介:孫京華,女,1949年8月出生,上海人,副教授.聯(lián)系電話:027—83663333,13317198997;E—mail:zhangyuzhao~126.comAhoatSUNJing-Hua:F~-nale,bominjBt,1949.A.,~ciateprofessor.Tel:+86—27—83663333,1331
2、7198—997;E-mail:zhangyuzha~126.coHq收稿日期:20o5—10—27修回日期:2006—02—16本文編輯:周志新作者單位:430030湖北省武漢市,華中科技大學同濟醫(yī)學院附屬同濟醫(yī)院眼科Receiveddate:Oct27,2005Accepteddate:Feb16,2006FtomtheDepartmentofOphthal—mology,TongiiHospitalAffiliat—edtoTongjiMedicalCollege,HuazhongUniversity
3、ofScienceandTechnology,Wuhan430030,Hube/Prov/nce,ChinaVEGF和PEDF在實驗性大鼠角膜新生血管組織中的動態(tài)表達孫京華張煜昭王慧王凈信劉常明DynamicexpressionofVEGFandPEDFinex.perimentalratcornealneovascularizationtis.SUeSSUNJing—Hua,ZHANGYu-Zhao,WANGHui,WANGJin9-Xin,LIUChang-Ming【Keywordslvasculare
4、ndothelialgrowthfactor;pigmentepitheliumderivedfactor;alkaliburn;cornealneovascularization【Abstract】ObjectiveTosttidythedy.amlcexpressionsandeffectsofvas--cularendothelialgrowthfactor(VEGF)andpigmentepitheliumderivedfac-tor(PEDF)inthedevelopmentofexperimen
5、talratcornealneovascularization(CNW).MethodsRatcornealalkalineburnmodelwasestablishedbyroutinemethod.ImmunereactionsofVEGFandPEDFweredetectedonthe1st,3rd,5th,7th,10thand14thdayrespectivelyaftertheburn,andtheproteinexPres-sionsweremeasuredbyimage-analysissy
6、stem.Resul協(xié)InCNVtissues.thepositiveinlnlunereactionofVEGFwasmostapparentduringthe3rd～7thdayandthendeclinedremarkablyonthe14thday.Certaintime-correlationexistedbetweenthedynamicexPressionsofVEGFandPEDFandthedevelopmentofCNW.ConclusionTheexpresslonsofVEGFand
7、PEDFareremarkablyex-pressedinexperimentalratCNVtissues,andthefluctuateofwhichisconsis-tentwiththedevelopmentofCNVebreakdownofthebalancebetweenthetwofactorsmayPlaYaroleinCNVoccurrenceanddevelopment.IRecAdvOphthalmol2006;26(8):573-576J【中圖分類號】Q959.836;R772【文獻
8、標識碼】A【文章編號】1003—5141I2006)08—0573-04【關鍵詞】血管內(nèi)皮生長因子;色素上皮衍生因子;堿燒傷;角膜新生血管【摘要】目的探討血管內(nèi)皮生長因子vascularendothelialgrowthfactor,VEGF)和色素上皮衍生因子(pigmentepitheliumderivedfactor,PEDF)在實驗性大鼠角膜新生血管(com~lneovascularization,CNV
