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《年產(chǎn)15噸的替米沙坦原料藥車間工藝設(shè)計(jì)設(shè)計(jì)》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在工程資料-天天文庫。
1、專業(yè)資料摘要本設(shè)計(jì)為年產(chǎn)15噸的替米沙坦車間工藝設(shè)計(jì)。在本設(shè)計(jì)中，我采用4-甲基-2-正丙基-1H-苯并咪唑-6-甲酸和N-甲基鄰苯二胺為原料經(jīng)過環(huán)縮合反應(yīng)后，與4’-溴甲基聯(lián)苯-2-甲酸甲酯發(fā)生取代反應(yīng)，最后經(jīng)過水解反應(yīng)生成替米沙坦粗品的過程。該設(shè)計(jì)的主要步驟為環(huán)縮合、取代反應(yīng)、和水解反應(yīng)，產(chǎn)率依次為71.2％、82％和86％。根據(jù)任務(wù)書要求，設(shè)定301天為基準(zhǔn)，替米沙坦的年產(chǎn)量為15噸。在本設(shè)計(jì)中，我們先是通過查閱文獻(xiàn)資料對(duì)替米沙坦和及其原輔料中間產(chǎn)品各種物性參數(shù)進(jìn)行了查詢和記錄，然后，了解了它的臨床用途、不良反應(yīng)和各
2、種藥理毒理反應(yīng)。然后根據(jù)設(shè)計(jì)繪制了工藝流程框圖。其次，我們以反應(yīng)釜為單位進(jìn)行了物料衡算，并且列出了反應(yīng)釜的進(jìn)出物料平衡表。在以上基礎(chǔ)上，完成物料衡算和設(shè)備選型，并繪制了帶控制點(diǎn)的工藝流程圖[1]。然后根據(jù)《藥品生產(chǎn)管理規(guī)范》等，并依據(jù)設(shè)計(jì)實(shí)際情況，進(jìn)行了詳細(xì)的勞動(dòng)人員安排。最后根據(jù)生產(chǎn)中的廢棄物的性質(zhì)和排出量，制定了合理利用和“三廢處理”辦法?！娟P(guān)鍵詞】年產(chǎn)15噸的替米沙坦；物料衡算；熱量衡算學(xué)習(xí)資料分享專業(yè)資料AbstractThedesignof15tonsoftelmisartanworkshopprocessdes
3、ign.Inthisdesign,Iuseis4-methyl-2-propylbenzeneand1h-imidazole-6-formicacidandN-methylo-phenylendiamineasrawmaterialafterringcondensationreaction,and-brominebiphenyl,4'-2-methylformatesubstitutionreaction,finallyafterhydrolysisreactionofalcoholtelmisartanprocess.T
4、hemainstepsofthedesignforthecycliccondensation,substitutionreaction,hydrolysisreaction,andtheyieldwas71.2%,82%and86%inturn.Accordingtothespecificationrequirements,setfor301daysasabenchmark,telmisartanoutputof15tons.Inthisdesign,wefirstthroughtheliteraturedataoftel
5、misartananditsrawmaterialsofvariousphysicalparametersinthequeryoftheintermediateproductsandtherecords,then,tounderstanditsclinicaluse,adversereactions,andallkindsofpharmacologyandtoxicology.Thenaccordingtothedesigndrawingtheprocessflowdiagram.Second,weinthereactio
6、nkettlehascarriedonthematerialbalance,andliststhereactionkettleinandoutofthematerialbalance.Onthebasisofabove,completethematerialbalanceandequipmenttypeselection,anddrawaprocessflowchartwithcontrolpoints.Thenaccordingtothecodeforthepharmaceuticalproductionmanageme
7、nt,etc.,andaccordingtothedesignoftheactualsituation,hascarriedonthedetailedlaborpersonnelarrangement.Finally,accordingtothenatureofthewasteintheproductionanddischarge,formulatemeasuresforreasonableutilizationand"threewastes".【keyword】Annualoutputof15tonsoftelmisar
8、tan;Materialbalance;Heatbalance學(xué)習(xí)資料分享專業(yè)資料摘要IAbstractII第一章產(chǎn)品概述11.1基本信息、化學(xué)結(jié)構(gòu)、性狀與規(guī)格11.1.1產(chǎn)品名稱11.1.2化學(xué)結(jié)構(gòu)、分子式、分子量11.1.3性狀與規(guī)格11.2產(chǎn)品藥理毒理21.3適應(yīng)癥與不良反應(yīng)21.4用法用量31.
