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1、DiseasesoftheHeartMajorDeterminantsofDiseaseMostheartdiseaseistheresultofatheroscleroticobstructionofthecoronaryarteriesCongestiveheartfailureismechanicalfailureofthehearttoejectblooddeliveredtoitMetabolicorautoimmunediseasemaycauseheartmuscleorvalvedamageHighbloodpressureac
2、celeratesatherosclerosis&mostothercardiacdiseaseCardiacvalvesareone-waygatesforbloodflow&aresusceptibletoobstruction®urgitationCardiacvalvesaresusceptibletoinfectionAbnormalembryonicdevelopmentoftheheartproducessignificantcardiacanatomicmalformationsAbnormalheartbeatpatte
3、rns(arrhythmias)cancausecardiacdysfunctionordeath&cancomplicateanyheartconditionArrhythmiasMechanicallyinefficientCOdecreasesPotentiallyfatalCausedbymyocardialischemiaMIelectrolyteimbalancestresscaffeinedrugs,especiallystimulantscongenitaldefectsintheelectricalnetworkNormalr
4、hythmis~70beats/minbradycardiais<60beats/mintachycardiais>100beats/minPrematureatrialcontractionsextraatrialbeatscommoninhealthypeoplenotharmfulduetostresslackofsleepcaffeinesomedrugsAtrialflutterrapid,regularatrialrhythm~300beats/minAtrialfibrillationrapid,irregularatrialrh
5、ythmAVnodefiltersoutalotdecreasedCOEachyearheartdiseaseaccountsforabout1/3ofdeathsintheUS,mostofwhichareassociatedwithcoronaryarteryatherosclerosis.Ifcerebrovasculardisease,vascularcomplicationsofdiabetes,&othervasculardiseasesareincluded,thefigureisover40%.Afterage40thelife
6、timeriskfordevelopingsymptomaticcoronaryarterydiseaseis50%inmen&40%inwomen.HeartBlockAtrialsignalisdelayed&cannotcrossintotheventricleCommoncauseisanatomicabnormalitiesCanalsobecausedbydigitalis1stdegreedelayofsignalbutnomissedventricularbeats2nddegreedelaylongenoughtocausem
7、issedventricularbeats3rddegreetotalblockofatrialsignaldecreasedCOPrematureventricularcontractionsoccurinhealthypeoplechestpalpitations&anxietyVentriculartachycardiaspontaneous,regularbeatingat>120beats/mindecreasedCOVentricularfibrillationextremelyrapid&irregularnegligibleCO
8、CongestiveHeartFailureCHFHeartunabletoejectvolumeofblooddeliveredtoitEndpoi