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1、地佐辛超前鎮(zhèn)痛在人工流產(chǎn)術(shù)的臨床研究廣東省肇慶市端州IX婦幼保健院526040【摘要】目的觀察地佐辛超前鎮(zhèn)痛聯(lián)合丙泊酚在人工流產(chǎn)術(shù)中的鎮(zhèn)痛效果和不良反應(yīng)。方法早孕婦女120例，ASAI?II級(jí)，停經(jīng)6?10周。無心血管疾患，無手術(shù)及麻醉藥物禁忌。隨機(jī)分成3組，每組40例。A組：地佐辛5mg與丙泊酪復(fù)合靜脈麻醉；B組：芬太尼lμg·kg-l與丙泊酪復(fù)合靜脈麻醉，C組：單純丙泊酚靜脈麻醉。三組丙泊酚誘導(dǎo)劑量均是2mg·kg-lc觀察指標(biāo):包括生命體征，誘導(dǎo)時(shí)間，蘇醒時(shí)間，離院時(shí)間，丙泊酚總用量，術(shù)中（體動(dòng)）、術(shù)后（下腹痛）的鎮(zhèn)痛效果和不良反應(yīng)。結(jié)果A,B兩組的誘導(dǎo)
2、時(shí)間，丙泊酚總用量明顯少于C組，有統(tǒng)計(jì)學(xué)意義（P0.05）;蘇醒、離院時(shí)間三組沒有明顯的差異；鎮(zhèn)痛效果比較：三組患者術(shù)中鎮(zhèn)痛效果A,B兩組占優(yōu)秀的顯著高于C組，有統(tǒng)計(jì)學(xué)意義（P0.05），患者術(shù)后下腹疼痛程度的VAS評(píng)分，A,B兩組顯著輕于C組，有統(tǒng)計(jì)學(xué)意義（P0.05）;在呼吸抑制方面A,C兩組顯著輕于B組，有統(tǒng)計(jì)學(xué)意義（P0.05）。A組生命體征較平穩(wěn)。結(jié)論地佐辛超前鎮(zhèn)痛聯(lián)合丙泊酚麻醉用于人流術(shù)優(yōu)于芬太尼聯(lián)合丙泊酚麻醉和單純異丙酚麻醉，安全，有效，值得臨床推廣使用。【關(guān)鍵詞】地佐辛；超前鎮(zhèn)痛；丙泊酚；人工流產(chǎn)術(shù)[Abstract]Objective：Toobservetheanalgesi
3、ceffectofdezocinepreemptiveanalgesiacombinedwithpropofolinartificialabortionandadversereaction.Methods120casesofearlypregnancywomen,ASAI?II，6?10weeksmenolipsis.Nocardiovasculardisease，nooperationandanesthesiadrug.Wererandomlydividedinto3groups，40casesineachgroup.GroupA：dezocine5mgandpropofolintraven
4、ousanesthesia；groupB：1gkg-1,fentanylandpropofolintravenousanesthesia，groupC：simpleintravenousanesthesiawithpropofol.Threegroupsofpropofolinduceddosewas2mg?kg-1.Observationindexes：includingvitalsigns，inductiontime,recoverytime,thetimetoleavethehospital，thetotaldosageofpropofol，intraoperative,postoper
5、ative(motion)(abdominalpain)ofanalgesiceffectandadversereaction.TheresultsofA,Btwogroupsofinductiontime，totaldosageofpropofolwasobviouslylessthangroupC，withstatisticalsignificance(P0.05)；awake，leavehospitaltimethreegroupshadnoobviousdifferences；tocomparetheanalgesiceffect：theanalgesiceffectofpatient
6、sinthreegroupsofA,BtwogroupwassignificantlyhigherthanthatofCgroupaccountedforgood,therearestatisticssignificance(P0.05)inpatientswithpostoperativeabdominalpaindegree,VASscore,A,BtwogroupwassignificantlylighterthanthatofCgroup，therewasstatisticalsignificance(P0.05)；theinhibitionofAonrespiration，Ctwog
7、roupwassignificantlylighterthanthatofBgroup,therewerestatisticallysignifican(tP0.05).VitalsignswerestableingroupA.Conclusiondezocinepreemptiveanalgesiacombinedwithpropofolanesthesiaforinducedabortioni
