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1、363例重癥監(jiān)護病房患者感染病原菌分布及耐藥性分析梁玉蘭張曉凱趙新惠潘士虎田新村(山東省濱州市中心醫(yī)院檢驗科山東惠民251700)【摘要】目的：了解重癥監(jiān)護病房(ICU)患者感染病原菌分布特點及耐藥情況，為控制醫(yī)院感染及臨床選用抗菌藥物治療提供依據。方法：分析2011年12月-2014年12月ICU患者送檢的各類標木中分離岀的病原菌，進行病原菌耐藥性分析。結果:分離出病原菌363株，標木來源中痰液陽性標木居首位，占77.4%;病原菌仍以革蘭陰性桿菌為主，占69.7%,革蘭陽性球菌占6.9%，真菌占總構成比23.4%。肺炎克雷白桿
2、菌和大腸埃希菌產超廣譜β-內酰胺酶(ESBLs)檢出率分別61.2%和75%，耐甲氧丙林葡萄球菌(MRSA)檢出率為48.5%。結論:ICU為醫(yī)院感染高發(fā)科室，病原菌仍以革蘭陰性桿菌為主，堅持細菌耐藥性監(jiān)測,?對ICU患者感染的診治只有重要指導意義。？【關鍵詞】？?重癥監(jiān)護病房;醫(yī)院感染;病原菌;耐藥性【中圖分類號】R446【文獻標識碼】A【文章編號】2095-1752(2015)13-0062-02Distributionofpathogensanddrugresistanceanalysisin363caseofI
3、CUpatientsLiangLulan，ZhangXiaokai,ZhaoXinhui,PanShihuTianXincun.CentralHosptalofBinzhou251700,China【Abstract】？Objective??To?investigate?pathogen?distribution?and?antimicrobial?resistance?in?the?intensive?care?unit?(ICU)?for?the?control?of?hospital?infection?and?guida
4、nce?of?antibiotic?clinical?use?of?drug?therapy.?Methods??From?December?2011-?December?2014.ICUpatientsforallkindsofspecimensinisolatedpathogens,pathogenicbacteriadrugresistanceanalysis.?Results??363?pathogens?were?isolated.Sputum-positive?samples?ranked??the?first?an
5、d?accounted?for?77.4%;?pathogenic?Gram-negative?bacilli?were?still?dominated,?accounted?for?69.7%?andGram-positive?cocci?accounted?for?6.9%,??fungi?accounted?for?23.4%?of?the?total?composition;PneumoniaCraywhiteCampylobacterandEscherichiacoli?ultra-extended-spectrum?
6、β-lactamases?（ESBLs）?had?a?detection?rate?of61.2%and75%?,?methicillin-resistant?Staphylococcus?aureus?（MRSA）?had?a??detection?rate?of?48.5?%.?Conclusion??The?rate?of?hospital?infection?was?high?in?ICU.?The?pathogens?were?mainly?Gram-negative?bacteria.?Bacterial?
7、resistance?surveillance?in??ICU?patients?would?be?helpful?for??hospital-acquired?infection?diagnosis?and?treatment.[Key?words]lntensive?care?unit;?Nosocomial?infection;?Pathogenic?bacteria;?Drug?resistance隨著抗菌藥物的廣泛應用，多重耐藥菌已成為醫(yī)院感染的重要病原菌，這種現象在ICU病房尤為突出。ICU患者病情較嚴重，長期接受了
8、大劑量的抗菌藥物,使機體免疫力低下，且廣泛使用各種侵入性操作，使ICU患者容易發(fā)生醫(yī)院感染[1】。ICU病房危重患者耐藥病原菌的不斷出現己經成為預防醫(yī)院感染的主要難題之一，為調査分析ICU病房危重患者的主要病原菌感染情況及耐藥性，為臨床合理使用抗菌藥物提供參考，
