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1、TipsforimprovingfilterlifeAquariusSystemCopyright?2015NIKKISOCo.,LTD.Allrightsreserved.PM-0063-11/2015-1腎臟替代治療“的內(nèi)容腎臟替代治療的基本內(nèi)容濾器的選擇抗凝劑的應(yīng)用3CRRT命名的發(fā)展CRRT:Continuousrenalreplacementtherapy(連續(xù)腎臟替代治療)ICBP:Intensivecarebloodpurification(重癥血液凈化)CBP:ContinuousBloodpurification(連續(xù)血液凈化)MOST:MultiOrga
2、nSupportTherapy(多臟器支持療法)4CRRT的特點和優(yōu)越性CRRT是緩慢、連續(xù)排除水分,模擬尿的排泄方式。更符合生理狀態(tài),能較好地維護(hù)血流動力學(xué)穩(wěn)定;容量波動??;溶質(zhì)清除率高;有利于營養(yǎng)改善及能清除細(xì)胞因子,從而改善危重ARF患者的預(yù)后,更好的血液動力學(xué)穩(wěn)定性更好的溶液控制能力和清除多余水分累積的更好溶質(zhì)清除性維持尿排泄并保存殘余腎功能清除炎癥介質(zhì)改善營養(yǎng)支持5CRRT的分類SCUF-緩慢連續(xù)超濾CAVH-連續(xù)動靜脈血液濾過CVVH-連續(xù)靜靜脈血液濾過HVHF-高容量血液濾過CAVHD-連續(xù)動靜脈血液透析CVVHD-連續(xù)靜靜脈血液透析CVVHFD-連續(xù)靜靜脈高
3、通量透析CAVHDF-連續(xù)動靜靜脈血液透析濾過CVVHDF-連續(xù)靜靜脈血液透析濾過MPS-血漿置換HP-血液灌流和免疫吸附CRRT以一種更符合機(jī)體生理特性的方式,連續(xù)地清除機(jī)體多余的水分和毒素,調(diào)節(jié)酸堿和電解質(zhì)的平衡,來有效地維持機(jī)體內(nèi)環(huán)境的穩(wěn)定。不單用于急性腎衰,還是救治許多危重病癥的有力輔助手段。6原理與機(jī)制彌散對流吸附500500050000SoluteClassesbyMolecularWeightDaltons?InflammatoryMediators(1,200-50,000)“small”“middle”“l(fā)arge”Jean-MichelLannoyNik
4、kisoABPDirector8炎癥介質(zhì)的特征介質(zhì)分子量C3a2500C5a2800TNF-a17500x3C5a2800IL-62125000IL-1Ra14000IL-89000LPS100000FactorD2300023000Jean-MichelLannoyNikkisoABPDirector9炎癥介質(zhì)的特征介質(zhì)蛋白結(jié)合分子量C3ano2500C5ano2800TNF-a部分17500x3STNRFIyes55000STNRFIIyes75000IL-621yes25000IL-1Rano14000IL-lano89000PAF部分450FactorDyes230
5、008/18/202110PSHF系列濾器篩選系數(shù)/高截留分子量如何選擇血濾器?Jean-MichelLannoyNikkisoABPDirector11MolecularWeights(分子的重量或分子量的大小)12Copyright?2015NIKKISOCo.,LTD.Allrightsreserved.Ashleyetall.TheRenalDrugHandbook,2ndEd.2004,MedicalPress,Abingdon,UK.ISBN:1857758730NewfunctionalmembranewithdefinedlargerporesizeHCOm
6、embrane?<0,01μm?<0,02μm?~0,09μm?~0,30μm?:porediameterhighfluxhighcut-off*proteinseparationmembraneplasmaseparationmembraneVariationofmembraneporesizeElectronmicrographsofinnermembranesurfacesievingcoefficient100100010000100000100000000.20.40.60.81Molecularweight[D]ClassicalFilter30kDhumank
7、idneyhighcut-offHighCut-OffHemofilterSievingCoefficientAsievingcoefficientisthemeasureofhoweasilyasubstancepassesfromthebloodcompartmenttothedialysatecompartmentinahaemofilter.Thus,asievingcoefficientof1.0meansthesoluteis100%filterable;i.e.inahaemofilter,theso