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1、授予單位代碼10089學(xué)號或申請?zhí)?6105中國圖書分類號R331HebeiMedicalUniversity碩士學(xué)位論文學(xué)術(shù)學(xué)位京尼平鞏膜交聯(lián)對兔實(shí)驗(yàn)性形覺剝奪性近視形成的影響研究生：趙亞芳導(dǎo)師：王超英教授專業(yè)：眼科學(xué)二級學(xué)院：白求恩國際和平醫(yī)院2018年3月目錄中文摘要····························································································1英文摘要··············································
2、··············································3研究論文京尼平鞏膜交聯(lián)對兔實(shí)驗(yàn)性形覺剝奪性近視形成的影響前言····························································································6材料與方法····························································································6結(jié)果··········
3、··················································································9附圖····························································································11附表····························································································18討論···
4、·························································································22結(jié)論····························································································26參考文獻(xiàn)·························································································
5、···26綜述京尼平鞏膜膠原交聯(lián)防治病理性近視的研究進(jìn)展·······················30致謝····························································································38個(gè)人簡歷····························································································39京尼平鞏膜交聯(lián)對兔實(shí)驗(yàn)性形覺剝奪性近視形成的影響摘要目前全球近視人
6、口不斷增加，近視已成為一種普遍社會現(xiàn)象，大部分近視的發(fā)展主要是在學(xué)齡期，而在成年后基本穩(wěn)定。其中高度近視又稱病理性近視，所導(dǎo)致的眼軸延長，后鞏膜葡萄腫，增加了近視眼的致盲率.這使得數(shù)以千萬計(jì)的國人生活質(zhì)量顯著降低，并消耗了大量的社會資源，因此尋找安全、有效的防治近視的治療方法，日益成為生命醫(yī)學(xué)科學(xué)領(lǐng)域急需解決的一項(xiàng)重大課題。目的：探討京尼平后Tenon’s囊下注射對兔實(shí)驗(yàn)性形覺剝奪性近視形成及發(fā)展的影響。方法：14d齡新西蘭幼兔40只，雌雄不限，測量雙眼屈光度，均以右眼為實(shí)驗(yàn)眼，左眼為對照眼。室溫20-23℃，白天用自然光照射，光照與黑暗的周期比例為12
7、h:12h。隨機(jī)分成A、B兩組，每組20只，A組為對照組，實(shí)驗(yàn)眼行單純縫合眼瞼，B組為實(shí)驗(yàn)組，實(shí)驗(yàn)眼行眼瞼縫合+后Tenon’s囊下注射0.5mmol/L京尼平，第60天拆開實(shí)驗(yàn)眼眼瞼縫線，測量雙眼屈光度，玻璃體腔長度、眼軸長度，閃光視網(wǎng)膜電流圖（暗適應(yīng)3.0和明適應(yīng)3.0），取實(shí)驗(yàn)眼鼻上1：00位和顳下7：00位鞏膜及對照眼相應(yīng)部位鞏膜，制作成5mm*10mm的鞏膜條帶，測量其厚度及彈性模量，蠕變率，極限應(yīng)力，極限應(yīng)變。用光學(xué)顯微鏡觀察視網(wǎng)膜、視神經(jīng)、鞏膜組織的變化。采用SPSS20.0軟件對數(shù)據(jù)進(jìn)行配對t檢驗(yàn)和獨(dú)立樣本t檢驗(yàn)作統(tǒng)計(jì)學(xué)分析。結(jié)果：1.屈
8、光度數(shù)和眼軸長度在形覺剝奪實(shí)驗(yàn)前，各組實(shí)驗(yàn)眼和對照眼比較，屈光度和眼軸長度的差異
