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《苦參堿和槐定堿對神經(jīng)可塑性的影響》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、寧夏醫(yī)科大學(xué)碩士學(xué)位論文英文摘要interpulseintervals(IPIs)from20to1000ms.Result:(1)Matrinecansignificantlyinhibitthebasalsynaptictransmissionbothinpopulationspike(PS)amplitudeandtheslopeofpopulationexcitatorypostsynapticpotential(pEPSPslope).MatrinecanalsoinhibittheinductionofLTPinP
2、Samplitude,buthadnosignificanteffectonpEPSPslope.Matrinealsohadnosignificanteffectontheresponsestopaired-pulsestimulation.TheinhibitoryeffectofmatrineonLTPinductionwasstillobservedwhentheratsweretreatedwithatropinebeforehand.Ontheotherhand,itwasnotobservedafterthera
3、tsweretreatedwithnaloxonepreviously.(2)SophoridinecansignificantlyincreasethebasalsynaptictransmissioninPSamplitudeafterintraperitonealadministration,buthadnosignificanteffectinpEPSPslope.SophoridinecansignificantlyincreasepEPSPslopeafterLTPinduction,buthadnoeffecti
4、nPSamplitude.Inaddition,sophoridinehadinhibitoryeffectontheresponsetopaired-pulsestimulation.Conclusion:Theresultssuggestthatmatrineinhibitsthebasalsynaptictransmissionandlong-termsynapticplasticityinPSamplitude,butnotshort-termsynapticplasticityinthedentategyrus.Ma
5、trineexertsitsinhibitoryeffectonLTPinductionmightberelatedtotheactivationofopioidreceptorsinDG.Ontheotherhand,sophoridinecanpromotethebasalsynaptictransmissioninPSamplitudeandtheinductionofLTPinpEPSPslope.Itispossiblethatincreasingneurotransmitterreleaseandelevating
6、theefficacyofthesynapticprocessispartlyresponsibleforthePPSinhibitioninducedbysophoridine.KEYWORDS:matrine;sophoridine;neuralplasticity;long-termpotentiation(LTP);paired-pulsestimulation;evokedpotential-6-寧夏醫(yī)科大學(xué)碩士學(xué)位論文英文摘要PARTTWOObjective:Toinvestigatetheepilepticsei
7、zure-likeeffectofsophoridineonelectro-encephalography(EEG)anditspossiblecharacteristicandthemechanismoftheseizure-likeeffect.Method:ChronicelectronimplantationwasemployedforIEEGrecordinginrat;andthetraditionalanti-seizuredrugswereforthemechanismstudyinmice.Result:Co
8、mparedwiththePPareaandTC,thegranulecellinDGisthemostsensitiveareainthekindlingeffectbys.c.sophoridine.Under-thresholdhypnoticdosageofdiaze
