資源描述：
《表面改性羥基磷灰石納米雜化粒子與復(fù)合材料的制備與表征》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在應(yīng)用文檔-天天文庫。
1、摘要的調(diào)節(jié)，制備了Gel／HA@Gel復(fù)合納米纖維和PLL～Gel／H[A@Gel三組分復(fù)合納米纖維。相對(duì)于未改性nHA，表面接枝改性的nHA在纖維中分散性明顯改善。通過上述研究，本論文提供了一種基于ATI沖對(duì)nHA進(jìn)行表面接枝改性的方法，并通過復(fù)合材料的制備驗(yàn)證了接枝改性對(duì)于提高納米無機(jī)粒子在聚合物基體中分散性的可能性，為制備具有更優(yōu)性能的骨再生修復(fù)材料提供了參考。關(guān)鍵詞：羥基磷灰石，原子自由基轉(zhuǎn)移聚合，聚乳酸，明膠，靜電紡絲北京化工大學(xué)碩：}：學(xué)位論文PREPARATIoNANDCHARACTEIUZ
2、ATIoNoFSURFACEMoDIFIEDHYDRoXYAPATITENANoHYRIDSANDCoMPoSITESABSTRACTTheartificialsynthesizednanohydroxyapatite(nHA)filledbi()degrad百blepolymerconlpositeiswidelyusedintheareaofbonetissueengineeringduetoitsverysimilari叫onthe·chemicalcompositionandstlllcturet
3、othenaturalhydroxyapatite(HA)inthebones．HoweVer，becauseoftheeas訂yaggregationofthenHAinthep01ymermatrix，itisimportanttoimproVethec()mpatibilityofHAnanoparticlesinbiodegradablepolymerstoobtaindesir￡Iblenanocompositesforbonetissueengineeringapplications．Inor
4、dertoimprovethedispersionofnHAinPoly(L—LactiIde)(PLLA)matrix，inthispaper，HAw’iththederiVedATRPinitiatorswasobtainedbypr印arationofHAfromprecursorsinthepresenceof3-aminopropyl一triethoxysilane(APTS)toproducetheHA吼lrfacewithterminal一NH2groups(HA—NH2)andreacti
5、onofthe-NH2gr()upsoftheHA—NH2nanoparticleswith2_bromoisobutyrylbromide(BIBB)toproducethe2-bromoisobutyryl一imm()bilizednanoparticles(HA—Br)．TheHA@PGMAandHA@PHEMAnanohy]bridsweresynthesizedthatthep01y(91ycidyllVmethacrylate)(PGMA)andthep01y(2_hydroxyeth姐met
6、hac巧late)(PHEMA)weregraRedf-romthesurfaceofnHAViaatomstransferradicalpolymerization(ATRP)，respectiVely．TheHA@PGMA—g’PLLAnanohybridsweregainedthrough‘‘GraRto’’methodthattheca而oxyl—tenninatedP01y(L—Lide)(PLLA．COOH)wasattachedontoHA@PGMAontothesurfaceofHAvia
7、reactionbetweenend—groups．W11ile，thehydroxylsontheHA@PHEMAsurfacewereusedtoinitiatetheringopeningpolymerizationofL一1actidetofomtheHA@PHEMA—g—PLLAnanohybridsby“GraR仔om”method．AnalysisincludingFTIR，XRD，TGA，DSC，SEMandTEMareusedtoprovethesuccess如1synthesisofd
8、ifIferentnanohybrids．Unexpectedly；theI．eweresomedisadvantagesinthesetwowaystoobtainPLLAgraRedHA．Inthefomer，althoughitwasgoodatcontr01ofattachedPLLAchain1ength，someoffinalHA@PGMA—g—PLLAdemonstratedinferiors01hbilityi
