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《同型半胱氨酸與2型糖尿病微血管病變的相關(guān)性-研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在教育資源-天天文庫。
1、山東省醫(yī)學科學院碩f研究生學位論交結(jié)論：本資料發(fā)現(xiàn)DN、DR組患者血漿tHcy水平明顯升高；高tHcy組的叫、DR發(fā)生率明顯高于iF常tHcy組，提示tHcy水平與糖尿病所特有的微血管并發(fā)癥的發(fā)生具相關(guān)性，Logistic回歸分析結(jié)果進一步顯示空腹高tHcy血癥是糖尿病微血管病變的獨立危險因素之一。本研究顯示高tHcy組血清FA、VitB．，均明顯降低，甲鉆氨F預(yù)治療后，血漿tHcy降低。提示VitB，：缺乏可能是誘發(fā)高they的一個重要因素。本研究尚顯示高tHcy組Scr明顯升高，提不腎小球濾過事降低也是誘發(fā)高tHcy的一個重要因素
2、，但糖尿病3組與c組中Scr水平并無锃著性差異，提不在Scr水平升高以前，糖尿病病人就存在tHcy水平的升高，高tHcy血癥與糖尿病的代謝紊亂有關(guān)。本資料還發(fā)現(xiàn)糖尿病3組與C組相比FBG、flbAle、TG及SBP等明顯升高，也提示高tHcy血癥也是糖尿病代謝紊亂的表現(xiàn)。關(guān)鍵詞：同型半胱氨酸2型糖尿病糖尿病‘腎病糖尿病視網(wǎng)膜病變4由東謄取擘轉(zhuǎn)學筏壤{硪究皇警建論芟StudyontheRelationshipBetweenTotalFastingPlasmaHomocysteine(tHcy)andMicroangiopathyinTy
3、pe2DiabetesMellitus(蚤渺PostgraduateZouxiaohuiSupervisorProfWanxuguangABSTRACTBackgroundandobjactive：Hyperhomocysteinemiahasbeenregardedastoberelatedtoadversevasculareffectssuchascardiacsuddendeath，stroke．pulmomaryembolism，andsoon．Recentresearchrevealedthathyperhomocystei
4、nemiaisrelatedtomacroangiographyinpatientswithtypeIId{abetesmellitus(DM)，butits’relationshiPwithdiabeticmicroangiographyremainsuncertain．ThegoalofthisstudyiStOobservetherelationshipbetweenhyperhomocyseinemiaanddiabetesmel11tusandits’chroniccomplications，investigatetheco
5、rrelationbetweentotalfastingplasmahomocysteine(tHey)andmicroangiopathyandthefactorsinfluencingplasmatHeyinpatientswithDM．Inaddition，toestimatethetherapeuticeffectstolowertheplasmatHeylevelofVitamineB12administration．Methods：SeventysevencasesoftypeIDMandtwentyonecasesofn
6、ormalindividualswereenrolledinthestudy。Thecaseswithtype2DMweredividedintothreegroupaccordingtoUAMlevelandanophthalmoscopeexamination：(1)32cases(14male)withoutcompiications(NDCgroup)，withanmeanageof56．84years．(2)22cases(10male)complicatedwithretinopathy(DRgroup)。withanav
7、erageageof59．77years．(3>Anothergroupwithnephropathy(DNgroup)。withanaverageageof58．55years．21casesofhealthyindividualswereenrolledintocontrolgroup．ThehyperhomOcysteinemiapatientspickedoutfromthiscohortweredevidedintotwogroups：oneiscontrolgroup(C)administeredwithplacebo，t
8、heothergroupistreatedwithmecobalamine．Datusofsystolicbloodpressure(SBP)，diastolicbloodpressure(DBP)，fastingblo
