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《體外誘導(dǎo)骨髓間充質(zhì)干細(xì)胞向神經(jīng)細(xì)胞分化的研究進(jìn)展》由會員上傳分享,免費在線閱讀,更多相關(guān)內(nèi)容在工程資料-天天文庫。
1、現(xiàn)代腫瘤醫(yī)學(xué)2015年04月第23卷第7期MODERNONCOLOGY,Apr.2015,VOL.23,NO.07·1027·[21]WashburnT,SchweighofferE,GridleyT,etal.Notchactivityin-[24]RealPJ,ToselloV,PalomeroT,etal.Gamma-secretaseinhibi-fluencesthealphabetaversusgammadeltaTcelllineagedecisiontorsreverseglucocorticoidresistancein
2、Tcellacutelymphoblastic[J].Cell,1997,88(6):833-843.leukemi[aJ].NatMed,2009,15(1):50-58.[22]WengAP,NamY,WolfeMS,etal.Growthsuppressionofpre-T[25]SchottAF,LandisMD,DontuG,etal.Preclinicalandclinicalacutelymphoblasticleukemiacellsbyinhibitionofnotchsignalingstudiesofgammasec
3、retaseinhibitorswithdocetaxelonhuman[J].MolCellBiol,2003,23(2):655-664.breasttumor[sJ].ClinCancerRes,2013,19(6):1512-1524.[23]KolbEA,GorlickR,KeirST,etal.Initialtesting(stage1)bythe[26]WuY,Cain-HomC,ChoyL,etal.Therapeuticantibodytarge-pediatricpreclinicaltestingprogramofR
4、O4929097,agamma-tingofindividualNotchreceptor[sJ].Nature,2010,464(7291):secretaseinhibitortargetingnotchsignaling[J].PediatrBlood1052-1057.Cancer,2012,58(5):815-818.(編校:賀魯寧)體外誘導(dǎo)骨髓間充質(zhì)干細(xì)胞向神經(jīng)細(xì)胞分化的研究進(jìn)展鄭蕊,廖承德,丁瑩瑩Researchprogressofbonemarrowmesenchymalstemcellswereinducedintone
5、rvecelldifferentiationinvitroZhengRui,LiaoChengde,DingYingyingDepartmentofRadiology,TheThirdAffiliatedHospitalofKunmingMedicalUniversity,TheTumorHospitalofYunnanProvince,YunnanKunming650118,China.【Abstract】Becauseoftheabilityofmulti-directionaldifferentiation,bonemarrowme
6、senchymalstemcellsarewide-lyused,especiallyinthetreatmentofneurodegenerativediseases.Alotofmethodscanbeused,alsotherearelotsoftraditionalChinesemedicineasinducers.Currentdifferentiationmethodsaredividedintotwocategories:chemicalder-ivationandtheculturetogether.Differentin
7、ductionmethodsleadtodifferentresults.Inthisoverview,bonemarrowmesenchymalstemcellswereinducedintonervecelldifferentiationinvitroandresearchprogresswerepresented.【Keywords】bonemarrowmesenchymalstemcells;inductionanddifferentiation;nervecell;researchprogressModernOncology20
8、15,23(07):1027-1029【指示性摘要】骨髓間充質(zhì)干細(xì)胞因其具有多向分化的能力,被廣泛應(yīng)用于臨床中,特別是用于治療神經(jīng)退行性疾病。體外誘導(dǎo)分化骨髓間充質(zhì)干細(xì)胞的方法很多,也有很多中