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1、分類號(hào)學(xué)號(hào)M200975830學(xué)校代碼10487密級(jí)碩士學(xué)位論文Hedgehog信號(hào)通路促進(jìn)卵巢癌上皮間質(zhì)化學(xué)位申請(qǐng)人：吳茜子學(xué)科專業(yè)：婦產(chǎn)科學(xué)指導(dǎo)教師：奚玲副教授答辯日期：2012年5月POSTGRADUATEDISSERTATIONHedgehogsignalingpromotesepithelial-mesenchymaltransitioninovariancancerCandidate:WuXiziMajor:GynecologyandObstetriesSupervisor:Viceprof.XilingCancerbiology
2、Center,TongjiHospital,TongjiMedicalSchool,HuazhongUniversityofScienceandTechnology,Wuhan,Hubei430030,P.R.ChinaMay,2012獨(dú)創(chuàng)性聲明本人鄭重聲明，本學(xué)位論文是本人在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果的總結(jié)。盡我所知，除文中已經(jīng)標(biāo)明引用的內(nèi)容外，本論文不包含任何其他個(gè)人或集體已經(jīng)發(fā)表或撰寫過(guò)的研究成果。對(duì)本文的研究做出貢獻(xiàn)的個(gè)人和集體，均已在文中以明確方式標(biāo)明。本人完全意識(shí)到本人將承擔(dān)本聲明引起的一切法律后果。學(xué)位論文作者簽名
3、：日期：年月日學(xué)位論文版權(quán)使用授權(quán)書本學(xué)位論文作者完全了解學(xué)校有關(guān)保留、使用學(xué)位論文的規(guī)定，即：學(xué)校有權(quán)保留并向國(guó)家有關(guān)部門或機(jī)構(gòu)送交論文的復(fù)印件和電子版，允許論文被查閱和借閱。本人授權(quán)華中科技大學(xué)可以將本學(xué)位論文的全部或部分內(nèi)容編入有關(guān)數(shù)據(jù)庫(kù)進(jìn)行檢索，可以采用影印、縮印或掃描等復(fù)制手段保存和匯編本學(xué)位論文保密□，在_____年解密后適用本授權(quán)書。本論文屬于不保密□。（請(qǐng)?jiān)谝陨戏娇騼?nèi)打“√”）學(xué)位論文作者簽名：指導(dǎo)教師簽名：日期：年月日日期：年月日目錄第一部分Hedgehog信號(hào)通路促進(jìn)卵巢癌上皮間質(zhì)化····················
4、·······1研究背景·····················································································1中文摘要·····················································································6英文摘要··················································································
5、···7材料與方法·················································································8實(shí)驗(yàn)結(jié)果···················································································18討論···························································································2
6、7參考文獻(xiàn)···················································································30第二部分綜述Hedgehog信號(hào)通路與上皮間質(zhì)化在腫瘤轉(zhuǎn)移中的研究進(jìn)展·······················································································35參考文獻(xiàn)························································
7、···························39致謝···························································································45華中科技大學(xué)碩士學(xué)位論文第一部分Hedgehog信號(hào)通路促進(jìn)卵巢癌上皮間質(zhì)化研究背景Hedgehog信號(hào)通路是一個(gè)高度保守的分子間信號(hào)轉(zhuǎn)導(dǎo)通路，首先在研究果蠅基因突變時(shí)發(fā)現(xiàn)的，它參與早期胚胎的形成(1)。后來(lái)在脊椎動(dòng)物中也發(fā)現(xiàn)Hedgehog信號(hào)通路也參與胚胎組織形成中的細(xì)胞生長(zhǎng)和分化，進(jìn)而也維持成
8、人干細(xì)胞的功能(2-5)。在哺乳動(dòng)物的Hedgehog信號(hào)通路中，有三種HH配體蛋白：Sonichedgehog(Shh)，Indianhedgehog(Ihh)和
