apelin-13對大鼠局灶性腦缺血—再灌注損傷的保護(hù)作用與其機制

《apelin-13對大鼠局灶性腦缺血—再灌注損傷的保護(hù)作用與其機制》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。

1、萬方數(shù)據(jù)ischemia-reperfusiongroup，thewatercontentofbraintissue，thevolumeandrateofinfarctweresignificantlydecreasedindosedependentmannerintheApelin·13(1．0and10．0ug&g)group(allP<0，05)。(3)Thestructureofbrainofratswasnormal，thenucleusofneuronwaslocatedinthecentreofc

2、ells，thedegenerationandnecrosisofneuronwerenotobservatedintheshamgroup．Comparedwiththeshamgroup，theamountofneuronwassignificantlydecreasedintheischemia—reperfusiongroup．Thetissueedema，thedegenerationandnecrosisofneuron，thekaryopyknosisandcaryolysisofnucleusw

3、ereobservatedinthegroup．Comparedwiththegroup，thestructureofbrainofratswasimproved，thedegreeofedema，karyopyknosisandcaryolysisofnucleuweresignificantlydecreasedandtheamountofdegenerationandnecrosisofneuronweresignificantlydecreasedintheApelin-13(1．0and10．0gg／

4、kg)group．(4)Comparedwiththegroup．theIevelofMDAandtheIevelofROSinthetissuebomogenateofbraintissueinthesurroundingareaofischemiaweresignificantlydecreasedindosedependentmannerintheApelin-13(1．0and10．0pg瓜曲group(allP

5、evelofGSHinthetissuebomogenateofbraintissueinthesurroundingareaofischemiaweresignificantlyincreasedindosedependentmannerintheApelin一13(1．0and10．0gg／kg)(allP

6、sueinthesurroundingareaofischemiaweresignificantlyup·regulatedindosedependentmannerintheApelin-13(1．0and10．0gg／kg)(allP<0．05)．Conclusion：Apelin-13protectstheinjury，whichthemechanismsmayberelatedwiththeinhibitionofoxidativestressandup—regulationofBDNFandTrkBi

7、nducedbyApelin-13．12figures，1tables，73references．Keyword：Apelin·13；Brainischemia—reperfusioninjury；Totalantioxidantcapacity；Reactiveoxygenspecies；MalondiaidehydeClassfication：R743V萬方數(shù)據(jù)目錄學(xué)位論文原創(chuàng)性聲明．．．??．???．???????．??．．I中文摘要．????．???．?????．????．??II英文摘要????．?．

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