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《醫(yī)藥級二硫代二苯并噻唑合成工藝-研究》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學術(shù)論文-天天文庫。
1、萬方數(shù)據(jù)青島科技大學研究生學位論文TheSyntheticTechnologyofMedicalGradeof2’2'-dibenzothiazoledisulfdeABSTRACTTheresearchtooktheindustrialMastherawmaterial，adoptingtheacidandalkalimethodtopurification，adoptingthegreenoxidant—hydrogenperoxide，usingthenontoxicandlownoxiousorganicreagent，theone—stepmethodsynthesizedthe
2、high—qualityDM．Theproductcouldimmediatelymeettherequestinmedicineproduction，thetechnologywasfeasible．ThestructureoftheproductwascharacterizedusingFT-IRand‘H-NMRtechnology,thepurityoftheproductwascharacterizedusingthemeltingpointapparatusandHPLC．Theproductwasmeasuredbulkdensity．111eorganicreagentwa
3、srecycledtomakesurethewholeprocesswaslowcostandcleanly．ThemethodwasestablishedandstudiedtomeasurethecontentofM．Thefactorsontheresultofacid—alkalimethodMpurificationsuchasthedosageofdeionizedwater,thedosageof32％NaOH，thedosageofactivatedcarbon，thetimeofadsorptionetc．a(chǎn)lwereinvestigated，theorthogonale
4、xperimentalandreproducibilityexperimentalweredesigned．TheresultsshowedthatwhenV(deionizedwater)：m(M)=5mL／g，V(32％NaOH)：m(M)=0．6mL／g，m(activatedcarbon)：m(M)21：20，thetimeofadsorptionwas1．5h，theproductwithhighmolecularweightwasobtained．Underthatconditions，theappearanceofproductwaswhitepowder,theyieldo
5、fproductwas97％，theinitialmeltingpointofproductwas1760C，thepurityoftheproductwas98％．ThefactorsontheresultofsolventmethodMpurificationsuchasthedosageofdeionizedwater,thedosageof32％NaOH，thedosageofactivatedcarbon，thetimeofadsorptionetc．a(chǎn)lwereinvestigated，theorthogonalexperimentalandreproducibilityexp
6、erimentalweredesigned．TheresultsshowedthatwhenV(deionizedwater)：m∽)210mL／g，V(32％NaoH)：m(M)=0。75mL／g，re(activatedcarbon)：m(M)21：20，thetimeofadsorptionwas3．0h，theproductwithhighmolecularweightwasobtained．Underthatconditions，theappearanceofproductwaswhitepowder,theyieldofproductwas96％，theinitialmelti
7、ngpointofproductwas176。C，thepurityoftheproductwas98％．ThemethodwasestablishedandstudiedtomeasurethecontentofM．TheIII萬方數(shù)據(jù)醫(yī)藥級二硫代為苯并噻唑合成工藝研究resultsshowedth,tattheexcesssodiumsulfitetriplehasfullysatisfiedtherequireme
