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1、№.3陜西科技大學(xué)學(xué)報(bào)Jun.2008Vol.26JOURNALOFSHAANXIUNIVERSITYOFSCIENCE&TECHNOLOGY·25·3文章編號(hào):100025811(2008)0320025205PROGRESSONCALCIUMPHOSPHATECEMENTPREPAREDASDRUGDELIVERYSYSTEMLIJuan2ying,HUANGJian2feng,CAOLi2yun(SchoolofMaterialsScienceandEngineering,ShaanxiUniversityofScience&Technology,Xi′an710021,Ch
2、ina)Abstract:Calciumphosphatecement(CPC)useasanoutstandingskeletaldefectrehabilitatematerialwasreportedthatithasbeenwidelyusedinclinicalpracticebecauseofitsexcellentpropertiessuchasbiocompatibility,bioactivity,self2settingandreleasingandsoon.Thelatestprogressoncalciumphosphatecementpreparedasd
3、rugdeliverysystemsuchasitsre2leasekinetics,effectivefactorsandphysiochemicalpropertieswerereviewed.Anditisalsopointedoutthattheexistingproblemsandthefutureresearchdirection.Keywords:calciumphosphatecement;drugdelivery;kinetics;physicochemicalpropertiesCLCNumber:R318.08;R944DocumentCode:A0Intro
4、ductionCalciumphosphatecement(CPC)isoneofthemostimportantbiomaterialsformedicalanddentalapplicationsbecauseofitsexcellentpropertiessuchasthebiocompatibility,bioactivity,self2setting,in2jectableandplasticityandsoon.Meanwhile,themulti2porousstructuremakesitgrowitselfthroughthebonetissuewhenimpla
5、ntedinthebody.Asdrugdeliverysystem,theclinicalstudyindicatesthatCPChasdistinctcurativeeffectsincuringandpreventingosteoporosis,bonearthritis,bonetraumaandcanc2erofbone,etc.duetoitsmildself2settingconditions.Whenrepairedandfilledinthebonedamnifica2tion,theCPCcanalsoreleasethedrugstolocaltissuec
6、ontinuously.Thus,highconcentrationofthedrugsinlocaltissue,extendingthecuringtimeofmedicamentwillberealizedandalmostwon′tbepoi2sonous.Atthesametime,itishelpfultofurtherchemotherapy,reducingoftherecurringaswellasthepreventingandinfectingofthecut,andeventhecuringofthechronicosteomyelitis.[1]Atpre
7、sent,CPCusedincliniciscomposedbysolidphaseandliquidphase.Thesolidphasemostlyincludetetracalciumphosphate(TTCP,Ca4(PO4)2O),dicalciumphosphatedidydrate(DCPD,CaHPO4·2H2O),tricalciumphosphate(TCP,Ca3(PO4)2O)andhydroxyapatite(HAP,Ca10(PO4)6(
