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1、www.impactaging.comAGING,April2016,Vol8No4EditorialMetronomicchemotherapyfortriplenegativebreastcancer?TeresaDiDesidero,RobertS.Kerbel,andGuidoBocciBreastcancerriskvarieswidelyandincreaseswithage.anexample,metronomicoralvinorelbinewasDespitetheincidenceforwomenolderthan70years
2、investigatedinatleasttwophaseIItrialsresultinginbeing33%,theyareusuallyexcludedfromscreeninggoodtolerabilityandsafetyprofileinthiselderlyschedulesandclinicaltrials.Furthermore,about15%ofpopulationwithasatisfactorypatientadherencetobreastcancersinolderpatientsareofthetriple-neg
3、ativetherapy[1].subtype(TNBC),whichisknowntobeanaggressiveRecently,anewpreclinicalscheduleofmetronomichistologicalsubtypewithverylimitedtreatmentoptionstopotecancombinedwithanantiangiogenicagentsuchavailable,andassociatedwithaverypoorprognosis[1].asatyrosinekinaseinhibitor(i.e
4、.pazopanib)wasfoundIndeed,theclinicalmanagementofelderlyfrailpatientstocausesignificantenhancementofantitumorefficacywithTNBCcanbecomplexanddifferentfromalltheofthetherapy,accompaniedbylowtoxicity,invariousotherbreastcancersubtypes.Age-relatedfactorssuchtumormodelssuchasrenalc
5、ellcarcinoma[4]andascomorbidities,deteriorationofcognitivefunction,advancedhumanovariancancer[5,6]andpediatricpossibleimpairmentinorganfunctionandthecancers[7].Topotecan,atopoisomeraseIinhibitor,concomitantuseofotherdrugs,mustbecarefullyappearstobehighlyefficaciousinanimalmode
6、lsandassessedtoavoidorminimizetoxicityrisks.Inthismoretolerableinhumanpatientswhenadministeredforcontext,lowdosemetronomicchemotherapymightprolongedperiodsusingmetronomicdosing,withoutrepresentapromisingtherapeuticoptionforelderlycausingsignificantpharmacokineticdruginteractio
7、ns.TNBCwomen[1].MetronomicchemotherapyreferstoRegardingtheefficacyofthecombinedtreatment,ourtheclose,regularadministrationofconventionalgrouprecentlypublishedpromisingdatainahumanchemotherapydrugsatlow,minimallytoxicdoses,withTNBCmetastaticmodel[2].Indeed,thepotentialnoprolong
8、edbreakperiods[2].Ithasbeenshowntotherapeuticimpactandthemole
