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1、s授予單位代碼10089學(xué)號或申請?zhí)?0122271HebeiMedicalUniversity碩士學(xué)位論文科學(xué)學(xué)位Twist基因誘導(dǎo)絨癌細(xì)胞上皮-間質(zhì)轉(zhuǎn)化的研究研究生：馬丹丹導(dǎo)師：龐義存教授專業(yè)：婦產(chǎn)科學(xué)2015年3月河北醫(yī)科大學(xué)學(xué)位論文使用授權(quán)及知識產(chǎn)權(quán)歸屬承諾本學(xué)位論文在導(dǎo)師（或指導(dǎo)小組）的指導(dǎo)下，由本人獨立完成。本學(xué)位論文研究所獲得的研究成果，其知識產(chǎn)權(quán)歸河北醫(yī)科大學(xué)所有。河北醫(yī)科大學(xué)有權(quán)對本學(xué)位論文進(jìn)行交流、公開和使用。凡發(fā)表與學(xué)位論文主要內(nèi)容相關(guān)的論文，第一署名為單位河北醫(yī)科大學(xué)，試驗材料、原始數(shù)據(jù)、申報的專利等知識產(chǎn)權(quán)均歸河北醫(yī)科大學(xué)所有
2、。否則，承擔(dān)相應(yīng)法律責(zé)任。研究生簽名導(dǎo)師簽章:二級學(xué)院領(lǐng)導(dǎo)蓋章：月方日河北醫(yī)科大學(xué)研究生學(xué)位論文獨創(chuàng)性聲明本論文是在導(dǎo)師指導(dǎo)下進(jìn)行的研究工作及取得的研究成果，除了文中特別加以標(biāo)注和致謝等內(nèi)容外，文中不包含其他人已經(jīng)發(fā)表或撰寫的研究成果，指導(dǎo)教師對此進(jìn)行了審定。本論文由本人獨立撰寫，文責(zé)自負(fù)。研究生簽名：名拼導(dǎo)師簽章：年3月《日目錄中文摘要·················································································1英文摘要·······················
3、··························································4英文縮寫···············································································9研究論文Twist基因誘導(dǎo)絨癌細(xì)胞上皮-間質(zhì)轉(zhuǎn)化的研究前言··············································································10材料與方法······················
4、···············································11結(jié)果··············································································23附圖··············································································25附表································································
5、··············28討論··············································································30結(jié)論··············································································33參考文獻(xiàn)········································································34綜述Twist基因與婦科惡性腫瘤上皮-間質(zhì)
6、轉(zhuǎn)化的研究進(jìn)展··············38致謝·····················································································45個人簡歷···············································································46中文摘要Twist基因誘導(dǎo)絨癌細(xì)胞上皮-間質(zhì)轉(zhuǎn)化的研究摘要目的：絨毛膜癌（choriocarcinoma）簡稱絨癌(CC)，在妊娠滋養(yǎng)細(xì)胞疾病中（gestation
7、altrophoblasticdisease，GTD）惡性程度居于首位。其可繼發(fā)于包括足月分娩、異位妊娠、自然流產(chǎn)以及葡萄胎在內(nèi)的各種類型的妊娠。絨癌在女性生殖系統(tǒng)腫瘤中發(fā)病率雖不及宮頸癌、卵巢癌及子宮內(nèi)膜癌，但其發(fā)展迅速，早期即可轉(zhuǎn)移至肺、腦等重要臟器，惡性程度極高，嚴(yán)重危害著廣大女性的生命健康。因其對化療藥物極其敏感，絨癌成為首個能夠通過化療治愈的婦科實體腫瘤。但由于化療藥物種類及化療方案的選擇不當(dāng)，常導(dǎo)致腫瘤細(xì)胞耐藥的情形產(chǎn)生，使之成為化療失敗的最主要原因。滋養(yǎng)細(xì)胞腫瘤的發(fā)病與多方面因素有關(guān)，發(fā)病機(jī)制尚未明確，因此關(guān)于其發(fā)生、發(fā)展及耐藥方面的研究
8、一直是人們廣泛關(guān)注的話題。現(xiàn)已證實上皮-間質(zhì)轉(zhuǎn)化(epithelialmesenchymalt
