Hydrogen Bonding Catalysis and Redox Neutral Cascade Reactions.pdf

Hydrogen Bonding Catalysis and Redox Neutral Cascade Reactions.pdf

ID:34973853

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頁數(shù):131頁

時間:2019-03-15

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1、HydrogenBondingCatalysisandRedoxNeutralCascadeReactionsByMatthewK.VecchioneAThesissubmittedtotheGraduateSchool-NewBrunswickRutgers,theStateUniversityofNewJerseyInpartialfulfillmentoftherequirementsForthedegreeofMasterofScienceGraduatePrograminChemistryWrittenu

2、nderthedirectionofDr.DanielSeidelAndapprovedby--------------------------------------------------------------------------------------------------------------------------------------------NewBrunswick,NewJersey[January2011]ABSTRACTOFTHETHESISHydrogenBondingCatal

3、ysisandRedoxNeutralCascadeReactionsByMatthewKyleVecchioneThesisDirector:Dr.DanielSeidelMythesisisdividedintotwoparts;hydrogenbondingcatalysisandredoxneutralcascadereactions.Relatingtohydrogenbondingcatalysis,Iwassuccessfulinperforminganadditionofisothiocyanato

4、imidestoα-ketoesters,withtheultimategoalofsynthesizingbeta-hydroxy-alpha-aminoacids.Thenecessityofmoreconventionalmeanstodevelopcatalytic,enantioselective,anddiastereoselectiveroutestothesemoietiescanbeseenintheirpresenceinmanynaturalproducts,includingvancomyc

5、in.Redoxneutralchemistryhasgainedstrongpopularityduetoitsadvantageousqualities,including:itsgreen,environmental-friendlycharacteristics,lackofusingexpensiveorharmfuloxidantsandreductants,andabilitytobuildupmolecularcomplexitywithlimitednumberofsteps.Underthisb

6、ranchofchemistry,Iwasabletodevelopanacid-assistedindoleadditiontoortho-aminoaldehydesleadingtothesynthesisofquinolinederivatives.Thesecompounds,althoughnotstudiedextensively,havebeendiscoveredtobepotentsirtuinproteininhibitorsandprecursorstonumberofsimplenatur

7、alproducts,includingcryptosanguinolentine.Afurtherstudyevaluatingsecondaryaminobenzaldehydesandindoleshowsthatthesynthesisoftheantimalarialagentneocryptolepinecouldbeeasilyiiachieved.Thissimplemethodologyalsomakesitpossibletosynthesizeanaloguesofthisimportantn

8、aturalproduct.iiiTableofContentsAbstractii–iiiListoffiguresviListofschemesvii-xListoftablesxiChapter1–HydrogenBondingCatalysis?-hydroxy-α-aminoacids1,17Ideaofbifunctionalcatalysis2

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