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《tfeb介導(dǎo)的自噬在胃癌耐藥中的作用及其機(jī)制研究》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、分類號(hào)R735.2UDC616-006密級(jí)公開TFEB介導(dǎo)的自噬在胃癌耐藥中的作用及其機(jī)制研究蔡習(xí)強(qiáng)培養(yǎng)類別全日制學(xué)位類型學(xué)術(shù)學(xué)位一級(jí)學(xué)科(專業(yè)類)臨床醫(yī)學(xué)二級(jí)學(xué)科(專業(yè))內(nèi)科學(xué)（消化系病）研究方向胃癌耐藥指導(dǎo)教師樊代明教授（主任醫(yī)師）培養(yǎng)單位西京醫(yī)院消化病醫(yī)院二O一五年五月第四軍醫(yī)大學(xué)博士學(xué)位論文目錄縮略語表·······························································································1中文摘要············································
2、···················································3ABSTRACT···························································································7前言······························································································12文獻(xiàn)回顧··············································
3、················································14正文······························································································27第一部分自噬是胃癌細(xì)胞在化療藥物情況下的重要存活機(jī)制························271材料····························································································272方法
4、····························································································283結(jié)果····························································································344討論····························································································40第二部分MTORC1/T
5、FEB信號(hào)通路是化療藥物誘導(dǎo)自噬的關(guān)鍵通路···············431材料····························································································432方法····························································································443結(jié)果·································································
6、···························474討論····························································································52第三部分TFEB通過調(diào)控LAMP1介導(dǎo)的溶酶體功能和自噬發(fā)生，促進(jìn)胃癌耐藥541材料····························································································542方法···································
7、·························································553結(jié)果····························································································594討論·········································
