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《2,2',4,4'-四溴聯(lián)苯醚紫外光解及DNA損傷毒性研究》由會(huì)員上傳分享，免費(fèi)在線(xiàn)閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、腳Y¨jii●■-帥8M2Ⅲ0洲5Ⅲ8哪5ABSTRACTBrominatedflameretardantsarewidelyusedinplastics，electronics，construction，textilesandothermaterialsandproductsduetotheirgoodflame—retardantproperty．PBDEiscurrentlyoneofthemostpopularflameretardents．Studieshaveshownthat，PBDEsiSharmfulto
2、theecologicalenvironmentandhumanbody,suchastoxiceffectsorpotentialhealthhazardtoanimalliver,thyroid，reproductivityanddevelopment，neurologyandimmunesystemsandSOon．Inrecentyears，PBDEshavebeendetectedinvariousenvironmentalmediaandlivingorganisms，alsoinhumanfatandbrea
3、stmilkfordifferentconcentrationlevels．Sofar,BDE一47(2,2’，4，4’-tetrapolybrominateddiphenylether)iscurrentlythemostwidelydistributed，thehighestconcentrationsofbiologicalsamples，oneofthemosttoxicpolybrominateddiphenylethercongenersinlivingorganismsandhumanbeings，thusp
4、hotochemicalreactionisthemaindegradationpathwayofBDE47intheenvironment．Therefore，itisofgreatsignificancetostudythephotochemicalreactionofBDE47anditsDNAdamagetoxicity．Theworkofthispaperconsistsoftwoparts：ThefirstpartisthephotochemicalreactionstudiesofBDE47．BDE47sam
5、pleispreparedinourlab．，andthephotochemicalreactionsofitwereconductedin4differentsolventsandacetonitrilewithtwokindsofadditives，respectiBDE47infourreactionandphotolyacetonitrile>DMSO>methan01．ThereiSaninversecorrelationbetweenphotolysisrateandsolventpolarity,theles
6、spolarsolventsfavorBDE47photolysisreaction．PhotodegradationrateBDE47decreasedintheacetonitrileaddingCuOandCu20，indicatingthatoxidantandreductantarenegativetotheoccurrencephotolysis．ThephotolysisreactionBDE47ismainlyconsecutivedebrominationreaction，producinganumber
7、lower-brominateddiphenylethers，theabundancephotoproductsinvarioussolventsreflectthesolventeffecttothephotodissociationpathway．ThesecondpartisBDE47’SDNAdamagetoxicitystudies．Inthisstudy,cytotoxicitymicelymphocytesinducedbyBDE47andits’photoproductsistestbysinglecell
8、gelelectrophoresis(cometanalysis)method．Theresultsshowedthat：(DBDE47iscytotoxicityandinducedDNAdamagemicelymphocytes；thecytotoxicityincreasewiththeconce
