資源描述：
《樹突狀細(xì)胞在粘膜免疫中的作用及其機(jī)制探討2005》由會(huì)員上傳分享，免費(fèi)在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫(kù)。
1、國(guó)外醫(yī)學(xué)免疫學(xué)分冊(cè)2005年9月第28卷第5期?ForeignMedicalSciencesSectionofImmunology,September2005,Vol28.No.5&259&種豬胸腺至T細(xì)胞缺陷小鼠(無論裸小鼠,還是T細(xì)3?VagefiPA,IerinoFL,GianelloPR,etal.RoleofthethymusintransplantationtoleranceinminiatureSwine:#.Thethymusisrequiredduringthe胞剔除的去胸腺小鼠)均使受者實(shí)現(xiàn)了有效的免疫induct
2、ionphase,butnotthemaintenancephase,ofrenalallografttolerance力重建,表現(xiàn)為:在體外,胎豬胸腺移植物中成熟[J].Transplantation,2004,77(7):979985.的小鼠T細(xì)胞對(duì)同種異體抗原或絲裂原刺激的增殖4?ZhaoY,SwensonK,SergioJJ,etal.Skingrafttoleranceacrossadiscordant反應(yīng)及活化(CD25和CD69表達(dá))正常;在體內(nèi),蛋xenogeneicbarrier[J].NatMed,1996,2
3、(11):12111216.白抗原免疫后,在胎豬胸腺移植物中成熟的小鼠T5?ZhaoY,RodriguezBarbosaJI,SwensonK,etal.Highlydisparatexenogeneicskingrafttoleranceinductionbyfetalpigthymusinthymectomized細(xì)胞產(chǎn)生受者小鼠MHC限制的免疫應(yīng)答反應(yīng),體外mice:Conditioningrequirementsandtheroleofcoimplantationoffetalpig檢測(cè)可見T細(xì)胞對(duì)該抗原刺激的增殖反應(yīng)。相
4、反,liver[J].Transplantation,2001,72(10):16081615.無豬胸腺移植的去胸腺小鼠則在體外檢測(cè)不到T細(xì)6?ZhaoY,SwensonK,WekerleT,etal.ThercriticalroleofmouseCD4+胞對(duì)該抗原刺激的增殖反應(yīng);當(dāng)移植同種異體皮cellsintherejectionofhighlydisparatexenogeneicpigthymusgrafts[J].膚后,豬胸腺移植的無胸腺的小鼠可發(fā)生有效的排Xenotransplantation,2000,7(2):129
5、137.斥反應(yīng),而未移植豬胸腺的無胸腺的小鼠則無排斥7?ZhaoY,RodriguezBarbosaJI,SwensonK,etal.Theinductionofspecificpigskingrafttolerancebygraftingwithneonatalpigthymusinthymec同種異體皮膚移植物的能力;!當(dāng)用肺炎支原體感tomizedmice[J].Transplantation,2000,69(7):14471451.染T細(xì)胞剔除去胸腺的小鼠時(shí),大部分動(dòng)物患肺炎,8?RodriguezBarbosaJI,Z
6、haoY,BarthR,etal.EnhancedCD4reconstitution而胎豬胸腺移植的喪胸腺的小鼠則不患肺炎,證實(shí)bygraftingneonatalporcinetissueinaltemativelocationsisassociatedwith在豬胸腺移植物中新成熟的T瞎胞使受者表現(xiàn)出了donorspecifictoleranceandsuppressionofpreexistingxenoreactiveTcells對(duì)病原體感染的抗性。[J].Transplantation,2001,72(7):1223123
7、1.9?ZhaoY,SergioJJ,SwensonK,etal.Positiveandnegativeselectionof由此可見,通過移植異種胎豬胸腺可使受者外functionalmouseCD4cellsbyporcineMHCinpigthymusgrafts[J].J周重新建立有效的細(xì)胞免疫力。異種胸腺移植可能Immunol,1997,159(5):21002107.為AIDS晚期患者或其他由于胸腺功能障礙引起的10?ZhaoY,FishmanJA,SergioJJ,etal.Immunerestorationbyfeta
8、lpigthy免疫缺陷性疾病等提供新的治療手段或具有一定的musgraftsinTcelldipleted,thymectomizedmice[J].JImmunol,1997,輔助治療作用。參考文獻(xiàn)5
