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1、Int.J.RadiationOncologyBiol.Phys.,Vol.76,No.2,pp.583–596,2010Copyrightó2010ElsevierInc.PrintedintheUSA.Allrightsreserved0360-3016/10/$–seefrontmatterdoi:10.1016/j.ijrobp.2009.06.031PHYSICSCONTRIBUTIONRESULTSOFAMULTI-INSTITUTIONDEFORMABLEREGISTRATIONACCURACYSTUDY(MIDRAS)KRISTYK.BROCK,PH.D.,ONBEHALFO
2、FTHEDEFORMABLEREGISTRATIONACCURACYCONSORTIUMPrincessMargaretHospital,UniversityHealthNetwork,DepartmentsofRadiationOncologyandMedicalBiophysics,UniversityofToronto,Toronto,Ontario,CanadaPurpose:Toassesstheaccuracy,reproducibility,andcomputationalperformanceofdeformableimageregistra-tionalgorithmsun
3、derdevelopmentatmultipleinstitutionsoncommondatasets.MethodsandMaterials:Datasetsfromalungpatient(four-dimensionalcomputedtomography[4D-CT]),aliverpatient(4D-CTandmagneticresonanceimaging[MRI]atexhale),andaprostatepatient(repeatMRI)wereob-tained.Radiationoncologistslocalizedanatomicstructuresforacc
4、uracyassessment.Algorithmaccuracywasde-terminedbycomparingthecomputer-predicteddisplacementateachbifurcationpointwiththedisplacementcomputedfromtheoncologists’annotations.Thirty-sevenacademicinstitutionsandmedicaldevicemanufac-turerswithpublishedevidenceofactivedeformableimageregistrationcapabiliti
5、eswereinvitedtoparticipate.Results:Twenty-sevengroupsagreedtoparticipate;6didnotreturnresults.Sixteencompletedtheliver4D-CT,12thelung4D-CT,3theprostateMRI,and3theliverMRI-CT.Therangeofaverageabsoluteerrorforthelung4D-CTwas0.6–1.2mm(left–right[LR]),0.5–1.8mm(anterior–posterior[AP]),and0.7–2.0mm(supe
6、rior–inferior[SI]);theliver4D-CTwas0.8–1.5mm(LR),1.0–5.2mm(AP),and1.0–5.9mm(SI);theliverMRI-CTwas1.1–2.6mm(LR),2.0–5.0mm(AP),and2.2–2.6mm(SI);andtherepeatprostateMRIprostatedatasetswas0.5–6.2mm(LR),3.1–3.7mm(AP),and0.4–2.0mm(SI).Conclusions:Aninfrastructurewasdevelopedtoassessmulti-institutiondefor
7、mableregistrationaccuracy.Theresultsindicatelargediscrepanciesinreportedshifts,althoughthemajorityofdeformableregistrationalgorithmsperformedatanaccuracyequivalenttothevoxelsize,promisingtoimprovetreatmentp
