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1、Researchandteachingusinganimals:Regulation,ethics,andoversightEricSandgren,VMD,PhDAssociateProfessorofPathobiologicalSciencesChair,AllCampusAnimalCareandUseCommitteeHollyMcEntee,BA,MAIACUCAdministrator,UW-MadisonThecharacterofpublicsupportforuseofanimalsinbiomed
2、icalresearchishighlyvariableHowisthepollingquestionasked?Whoasksthequestion;whoisasked?Doesthequestionstatewhetherpossibleanimalpainordistressisapartoftheresearch?Educationis,sadly,deficient.UseofanimalsinresearchandteachingishighlyregulatedAnimalWelfareAct(AWA)
3、USDAAnimalCarePoliciesPublicHealthServicePolicy(OfficeofLaboratoryAnimalWelfare,OLAW)AAALAC:AssociationfortheAssessmentandAccreditationofLaboratoryAnimalCare,InternationalTheAnimalWelfareActPassedin1965bytheUSCongress;multipleamendmentsEnforcedbytheUSDA;failuret
4、ofollowthelawcanresultinfinesorjailUnannouncedinspectionsatleastonceperyearDoesnotcoverrats,mice,orbirdsbredforresearchAnimalWelfareAct--significantrequirementsTheInstitutionmusthaveanIACUC(InstitutionalAnimalCareandUseCommittee)TheInstitutionmustprovidefortheps
5、ychologicalwellbeingofnon-humanprimatesTheInstitutionmustprovideexercisefordogsPublicHealthServiceInstitutionsusingPHSfundsmustfollow“TheGuidefortheCareandUseofLaboratoryAnimals”(Guide)CoversallvertebratespeciesFailuretofollowtheGuidecanresultinlossoffundingtoth
6、einstitutionTheGuidedefinestherequirementsofaLaboratoryAnimal“Program”ProgramintegrationPhysicalplantAnimalenvironment,housing,andmanagementPersonnelqualificationsandtrainingOccupationalhealthandsafetyVeterinarymedicalcareIACUCInstitutionalofficialIACUCMusthavea
7、tleastalaboratoryanimalveterinarian,ascientist,andacommunitymembernotaffiliatedwiththeinstitutionandwhodoesnotuseanimalsinresearchReviewsallfacilitiesandprogramstwiceayear;identifiesandensurescorrectionofanydeficienciesReviews“Protocols”,theresearcher’sorteacher
8、’sproposalforanimaluseMonitorsanimaluse;cansuspendanyanimalactivitythatdoesnotmeetstandardsTheprotocolreviewprocess(simplified)AAALAC:AssociationfortheAssessmentandAc
