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1、JournalofPsychosomaticResearch48(2000)187±194Apresurgicalpsychosocialinterventionforbreastcancerpatients:psychologicaldistressandtheimmuneresponseMarkR.Larson*,PaulR.Duberstein,NancyL.Talbot,ChristopherCaldwell,JanA.MoynihanCenterforPsychoneuroimmunologyResearch,Un
2、iversityofRochesterMedicalCenter,300CrittendenBoulevard,Rochester,NY14642,USAAbstractObjective:Thepresentstudyevaluatedthefeasibilityandgery;and(3)atpostsurgery.Results:Examinationoftheim-potentialimmunologicalbene?tofapresurgicalinterventionmunologicaldatarevealed
3、evidenceofsuppressionofforbreastcancerpatients.Methods:Forty-onenewlydiag-interferon-g(IFN-g)inthecontrolgroupovertime,butnotnosedbreastcancerpatientswererandomizedintocontrolintheinterventiongroup.Secondary?ndingsrelatedtopsy-(standardcare)andinterventiongroups.In
4、additiontostan-chologicalassessmentgenerallyparalleledtheIFN-gresults.dardcare,interventiongroupmembersreceivedatwo-sessionConclusion:Therelevanceandapplicabilityofthese?ndingspsychosocialintervention.Bloodwasdrawnatthreetime-tofuturebreastcancerinterventionresearc
5、hisdetailed.points:(1)atpreintervention;(2)atpostintervention/presur-ó2000ElsevierScienceInc.Allrightsreserved.Keywords:Breastcancer;Intervention;Immunity;Interferon-g;Naturalkillercells;FeasibilityIntroductionmunesuppressionmayberelatedtopsychologicaldis-tress[22,
6、23].Stress-relatedimmunesuppressionmayWomendiagnosedwithbreastcanceroftenexperi-evencontinueintothepostsurgicalperiod.Forexample,enceahostofnegativeemotions,includinganger,fear,Andersenandcolleagues[24]concludedthathigherandhopelessness[1±4].Acrossavarietyofstressf
7、ullevelsofstresssigni?cantlypredictedlowerNKcelllysissituations,negativeemotionalresponsesareoftenparal-anddiminishedNKcellresponsetorecombinantIFN-gleledbypotentiallydeleteriousalterationsoftheim-invitro.muneresponse[5±8].Forexample,theexperienceofAssumingthatpsyc
8、hologicaldistressandimmunestresshasbeenlinkedtodepressedimmunefunction,suppressionarerelated,interventionsdesignedtohelpincludingreducednaturalki
