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1、Kimetal.SpringerPlus2013,2:299http://www.springerplus.com/content/2/1/299aSpringerOpenJournalRESEARCHOpenAccessSuccinatedehydrogenaseexpressioninbreastcancer*SewhaKim,DoHeeKim,Woo-HeeJungandJaSeungKooAbstractTheaimofthisstudywastoinvestigatesuccinatedehydrogena
2、se(SDH)expressioninbreastcanceraccordingtobreastcancermolecularsubtypeusingimmunohistochemistryandtoassesstheclinicalimplicationsofSDHexpression.ImmunohistochemicalstainingforER,PR,HER-2,Ki-67,HIF-1α,SDHA,andSDHBwasperformedontissuemicroarraysof721breastcancers
3、.AccordingtotheimmunohistochemistryresultsforER,PR,HER-2,andKi-67andfluorescenceinsituhybridization(FISH)resultsforHER-2,breastcancermolecularsubtypeswereclassifiedintoluminalA,luminalB,HER-2,andtriple-negativebreastcancer(TNBC).HER-2subtypebreastcancersmostfre
4、quentlyshowedhigh-levelexpressionofSDHAintumorcells,whiletheluminalAsubtypemostfrequentlyshowedlowornegativeexpressionofSDHAintumorcells(P=0.032).StromalSDHBexpressionratewashighestinHER-2subtypeandlowestinTNBC(P<0.001).SDHA-negativebreastcancerswereassociatedw
5、ithyoungerageatdiagnosis(P=0.012),andSDHB-negativebreastcancerswithlowerhistologicgrade(P=0.044)andlowerKi-67labelingindex(LI)(P=0.046).TumorphenotypesaccordingtotheSDHstatuswereSDHA(+)/SDHB(+)>SDHA(–)/SDHB(–)>SDHA(–)/SDHB(+)>SDHA(+)/SDHB(–)inorderoffrequency.T
6、hestromalphenotypeswereSDHA(–)/SDHB(–)>SDHA(+)/SDHB(+)>SDHA(–)/SDHB(+)>SDHA(+)/SDHB(–).Inconclusion,lossofSDHAorSDHBexpressionwasobservedinabout3%ofbreastcancersinthisstudy.LowSDHexpressionstatusinbreasttumorcellswasassociatedwithyoungerageatdiagnosisandlow-gra
7、dehistology.Keywords:Breast;Metabolism;Mitochondria;SuccinatedehydrogenaseIntroductionGermlineloss-of-functionSDHmutationsareassoci-Succinatedehydrogenase(SDH)(succinate-coenzymeQatedwithseveraltumorssuchaspheochromocytomaandreductase,respiratoryComplexII)catal
8、yzestheoxidationparaganglioma,gastrointestinalstromaltumor(GIST),ofsuccinatetofumaratewiththereductionofubiquinoneandrenalcellcarcinoma(Hensen&Bayley2011;toubiquinol.Through
