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1、MedicalHypotheses72(2009)247–249ContentslistsavailableatScienceDirectMedicalHypothesesjournalhomepage:www.elsevier.com/locate/mehyAdiposetissuetransplantationmaybeapotentialtreatmentfordiabetes,atherosclerosisandnonalcoholicsteatohepatitisMadhusudanaGirijaSanal*Specia
2、lCenterforMolecularMedicine,JawaharlalNehruUniversity,NewDelhi110067,IndiaDepartmentofGastroenterology,GBPantHospital,NewDelhi110002,IndiaarticleinfosummaryArticlehistory:Adiposetissueiscriticalinenergyhomeostasis.Adiposetissue‘buffers’thelipidsandenergyrichcom-Receiv
3、ed5October2008poundswhicharepumpedintothebloodstreamsoonaftermeals.Itsenses,signalsotherorganslikeliverAccepted13October2008andbrainabouttheenergyreservesviaadipokines.Adiponectin,themostabundantadipokinehasinsu-linsensitizing,anti-in?ammatoryantiatherogenicandantiste
4、atoticeffects.Adiposetissuedysfunctionisaccompaniedbyabnormallipiddistributionandstoragewhichcontributestodiseaseslikediabetes,non-alcoholicfattyliverdiseaseandatherosclerosis.Obesityandlipodystrophyareassociatedwithdysfunc-tionaladipocytes.Pre-adipocytesareeasytoisol
5、ateandculture.Apersonalizeddepotspeci?cliposuctiontoremovetheinactiveadipocytesfollowedbyadipocyterepopulationcouldbeusefulinthetreatmentofthesediseases.ó2008ElsevierLtd.Allrightsreserved.Toana?vereaderthetitlemightseemabsurdfordiseaseslikementininsulinsensitivityandd
6、ecreaseinhepaticsteatosis[3].diabetesatherosclerosisandnonalcoholicfattyliverdiseaseButinterestinglysurgicalremovalofexcessfatdoesnotimprove(NAFLD)areclassicallyassociatedwithobesity.Butconsideringinsulinsensitivity.Thisispossiblybecauseasadipocytesarere-theemergingro
7、leofadiposetissueasanendocrineorgancriticalmovedtheprotectionofferedbyadipokinesisdecreasedaswellinenergyhomeostasis,thechangeinrolefromvillaintoherobe-asthebufferingactionprovidedbyadipocytesonthecirculatingcomesacceptable[1–3].energyrichsubstrates[3,12].Thisadipocen
8、tricviewissupportedAdiposetissuetakesupandstorestheexcessenergyrichsub-bypopulationstudiesaswell.MutationsinPPAR-c(peroxisom
