Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer

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時(shí)間：2019-08-06

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1、BreastCancerResTreat(2011)127:69–80DOI10.1007/s10549-010-0972-2PRECLINICALSTUDYLet-7familymiRNAsregulateestrogenreceptoralphasignalinginestrogenreceptorpositivebreastcancerYingchunZhao?CaishuDeng?JiaruiWang?JingXiao?ZoranGatalica?RobertR.Recker?GaryGuishanXiaoReceived:10March2010/Accepted:26M

2、ay2010/Publishedonline:10June2010óSpringerScience+BusinessMedia,LLC.2010AbstractInordertounderstandhowmicroRNAs(miR-processinMCF7cells.Inconclusion,our?ndingsindicateNAs)regulatebreastcancertumorigenesis,amiRNAanewregulatorymechanismoflet-7miRNAsinER-aexpressionmicroarrayscreeningwasperformed

3、usingmediatedcellularmalignantgrowthofbreastcancer.RNAfromformalin-?xedparaf?n-embedded(FFPE)breasttissues,whichincludedbenign(n=13),ductalKeywordsLet-7familymicroRNAsBreastcancercarcinomainsitu(DCIS)(n=16),andinvasiveductalFFPEEstrogenreceptor-asignalingcarcinoma(IDC)(n=15).Twenty-?vediff

4、erentiallyexpressedmiRNAs(P