資源描述：
《Impact of Hydrophobic Chain Composition on AmphiphilicMacromolecule Antiatherogenic Bioactivity疏水鏈組成對兩親性的影響 高分子抗動脈粥樣硬化生物活性》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。
1、ThisisanopenaccessarticlepublishedunderanACSAuthorChoiceLicense,whichpermitscopyingandredistributionofthearticleoranyadaptationsfornon-commercialpurposes.Articlepubs.acs.org/BiomacImpactofHydrophobicChainCompositiononAmphiphilicMacromoleculeAntiatherogenicBioactivity???,§,?
2、,?AllisonFaig,LatrishaK.Petersen,PrabhasV.Moghe,andKathrynE.Uhrich*??§DepartmentofChemistryandChemicalBiology,DepartmentofBiomedicalEngineering,andDepartmentofChemicalandBiochemicalEngineering,RutgersUniversity,Piscataway,NewJersey08854,UnitedStates*SSupportingInformationAB
3、STRACT:Amphiphilicmacromolecules(AMs)composedofsugarbackbonesmodi?edwithbranchedaliphaticchainsandapoly(ethyleneglycol)(PEG)tailcaninhibitmacrophageuptakeofoxidizedlow-densitylipoproteins(oxLDL),amajoreventunderlyingatherosclerosisdevelopment.PreviousstudiesindicatethatAMhy
4、drophobicdomainsin?uencethisbioactivitythroughinteractingwithmacrophagescavengerreceptors,whichcancontainbasicand/orhydrophobicresidueswithintheirbindingpockets.Inthisstudy,wecomparetwoclassesofAMstoinvestigatetheirabilitytopromoteathero-protectivepotencyviahydrogen-bonding
5、orhydrophobicinteractionswithscavengerreceptors.Aseriesofether-AMs,containingmethoxy-terminatedaliphaticarmscapableofhydrogen-bonding,wassynthesized.ComparedtoanalogousAMscontainingnoethermoieties(alkyl-AMs),ether-AMsshowedimprovedcytotoxicitypro?les.IncreasingAMhydrophobic
6、ityviaincorporationoflongerand/oralkyl-terminatedhydrophobicchainsyieldedmacromoleculeswithenhancedoxLDLuptakeinhibition.These?ndingsindicatethathydrophobicinteractionsandthelengthofAMaliphaticarmsmoresigni?cantlyin?uenceAMbioactivitythanhydrogen-bonding.1.INTRODUCTIONcondi
7、tions),andasaresultoftheirsystemicadministrationandmechanismofactionstatinsdonotdirectlytreatatherogenicAtherosclerosis,amajorcauseofmortalityworldwide,isan10?12in?ammatorydiseasecharacterizedbyarterialplaquedevelop-sitesinthearteries.Whenstatinsarenottoleratedbyment.1?5Dur
8、ingtheearlystagesofatherosclerosis,low-densitypatientsorwhenpatientsaregenetically
