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1、是尿液，占12.4%；肺炎克雷伯菌對(duì)常用抗菌藥物均產(chǎn)生了一定的耐藥性，對(duì)氨節(jié)西林耐藥率最高，為98.1%；其次是頭抱哩卩林，為50.4%；對(duì)亞胺培南耐藥率最低，為3」％。結(jié)論木次硏究肺炎克雷伯菌主要分離自痰及下呼吸道分泌物，其次是尿液標(biāo)木,主要存在于重癥醫(yī)學(xué)科、呼吸內(nèi)科和普外科等科室，對(duì)常用抗菌藥物均產(chǎn)牛了一定的耐藥性，和國(guó)內(nèi)其他同類醫(yī)院對(duì)比分析，不同抗菌藥物存在不同差別，但和國(guó)外相關(guān)報(bào)道對(duì)比發(fā)現(xiàn)明顯高于某些西方發(fā)達(dá)國(guó)家，所以我們首先要加強(qiáng)重點(diǎn)患者、重點(diǎn)部位和重點(diǎn)科室的監(jiān)管工作，其次我們要繼續(xù)做好抗菌藥物敏感性試驗(yàn)，臨床醫(yī)生根據(jù)藥敏試騎結(jié)果
2、合理選用抗菌藥物，同時(shí)我們也要做好更務(wù)人員手衛(wèi)生，I矢院環(huán)境學(xué)監(jiān)測(cè)，加強(qiáng)院內(nèi)感染的控制，從而防止多重耐藥菌和醫(yī)院內(nèi)感染的發(fā)生。關(guān)鍵i司：肺炎克雷伯菌；標(biāo)本來(lái)源；抗菌藥物；耐藥性AbstractDistributionanddrugresistanceofKlebsiellapneumoniaeStrainsPostgraduateChenXiangyangTutorLiFuguangDepartmentofMicrobiologyandImmunology,CollegeofBasicMedicalScience,ZhengzhouUniv
3、ersity,Zhengzhou450001AbstractObjectiveThroughinvestigatingthedistributionandthedrugresistanceof516Klebsiellapneumoniaestrainswhichisolatedfromallclinicaldepartmentsspecimensof3localgeneralhospitals,theKlebsiellapneumoniaeinflectionanddrugresistancewasunderstoodbycontrasta
4、nalysingandcomparingwithotherhospitalareas,toprovidethebasisforclinicaluseofdrugsandnosocomialinfection.MethodsThroughisolatingpathogenicbacteriafromjudgedasqualifiedspecimensofallclinicaldepartmentsspecimenswhichfrom3hospitalsduringJanuary2014toDecember,identifyingbyFranc
5、ebioMerieuxAPIsystem,516Klebsiellapneumoniaestrainswasisolated.Drugsensitivitytoselectedantibioticswastestedbydiskdiffusionmethod,andtheresultwasinterpretedby2014CLSIstandard.WHONET5.6recommendedbytheMinistryofHealthwasusedinthestatisticalanalysisofalldatafordistribution,s
6、pecimensourceanddrugresistanceofKlebsiellapneumoniae?AbstractResultsTotally516Klebsiellapneumoniaestrainswereisolated.Thedetectionratewere21.7%whichcamefromtheintensivecareunitandsecondly14.7%whichcamefromtherespiratorymedicinedepartment.Thebacteriacontainingspecimenswere5
7、3.5%fromphlegmandlowerrespiratorytractsecretionand12.4%fromurine?Theresistancerateswere98.1%highesttoampicillin,50.4%secondlytocefazolin,and3」％lowesttoimipenem.ConclusionKlebsiellapneumoniaeweremainlyfromphlegmandlowerrespiratorytractsecretion,followedbyurine.Thebacteriaco
8、ntainingspecimensweredistributedinthemainunitssuchasintensivecareunit,respiratorymedicine
