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1、InducedpluripotentStemcells(iPScells)概述東北林業(yè)大學(xué)碩士論文答辯Backgroung誘導(dǎo)多能干細(xì)胞（InducedPluripotentStemCells，iPS細(xì)胞）。通過(guò)基因操作將某些因子導(dǎo)入細(xì)胞,使體細(xì)胞直接重構(gòu)成為多潛能干細(xì)胞。胚胎干細(xì)胞（Embryonicstemcells）成體干細(xì)胞（Adultstemcells）干細(xì)胞(StemCells)是一類(lèi)具有高度自我更新和多向分化潛能的細(xì)胞。Regenerativetherapy:Diabetes,Cancer,CerebralPalsy,etal致瘤性倫理分化效率東北林業(yè)大學(xué)
2、碩士論文答辯StemCellsStemCellsAdvantage1Embryonicstemcells東北林業(yè)大學(xué)碩士論文答辯iPSCellsfromMouseEmbryonicandAdultFibroblast2006.7,ShinyaYamanakaResearchprogressfibrolastiPScells東北林業(yè)大學(xué)碩士論文答辯Researchprogress2007.11,ShinyaYamanaka&James??ThomsoniPSCellLinesDerivedfromHumanSomaticCells東北林業(yè)大學(xué)碩士論文答辯Oct4-iPSc
3、ells09.02Researchprogress--safetyL-MycReplacedCre-loxPRemovedc－MycVirus-freeiPScells,MulticistronicVector/PlasmidSmall-MoleculeInhibitorofTgf-βSignalingInductioniPSCellsWithoutViralIntegration08.0909.0309.0409.1010.08東北林業(yè)大學(xué)碩士論文答辯HypoxiaEnhancestheGenerationofInducedPluripotentStemCellsRe
4、searchprogress--efficiencySuppressionofinducedpluripotentstemcellgenerationbythep53–p21pathwayiPSiPScellsfromadulthumanadiposestemcells09.0809.0809.09BAFComplexFacilitateReprogramming10.04東北林業(yè)大學(xué)碩士論文答辯Researchprogress--therapyPancreaticβ-cellsforDiabetesMedullarySheathDopamineneuronforPar
5、kinsonismCardiovascularcellAuditorynerveprogenitorcellforhearingimpairment08.1108.0508.1109.0310.0309.02neuralstemcellforinjuryofspinePlatelet09.02東北林業(yè)大學(xué)碩士論文答辯P53siRNA和UTF1可使iPS轉(zhuǎn)化效率可提高100倍小鼠腦膜細(xì)胞-iPS細(xì)胞建立大鼠/豬iPS細(xì)胞系0ct4與iPS細(xì)胞iPS細(xì)胞可在胚胎中正常發(fā)育iPS細(xì)胞注射入囊胚培育出健康小鼠培養(yǎng)過(guò)程中添加維生素C可使iPS誘導(dǎo)效率提高10倍08.1008.11
6、09.0209.0309.0709.0709.12羊水細(xì)胞誘導(dǎo)iPS09.08我國(guó)iPScell研究進(jìn)展東北林業(yè)大學(xué)碩士論文答辯iPierian,Inc.GenomeCenterofWisconsin,WisconsinNationalPrimateResearchCenter,UniversityofWisconsin-Madison.DepartmentofStemCellBiology,InstituteforFrontierMedicalSciences,KyotoUniversityDepartmentofCardiology,KeioUniversitySc
7、hoolofMedicine.Genentech,IncOrganization東北林業(yè)大學(xué)碩士論文答辯中國(guó)科學(xué)院上海生命科學(xué)研究院細(xì)胞生物學(xué)研究所中國(guó)科學(xué)院動(dòng)物研究所周琪研究組中科院廣州生物醫(yī)藥與健康研究干細(xì)胞與再生醫(yī)學(xué)研究所上海交通大學(xué)醫(yī)學(xué)院曾凡一實(shí)驗(yàn)室北京生命科學(xué)研究所北京大學(xué)細(xì)胞分化與干細(xì)胞實(shí)驗(yàn)室Organization東北林業(yè)大學(xué)碩士論文答辯鄧宏魁裴端卿周琪賀林leader東北林業(yè)大學(xué)碩士論文答辯WorldStemCells&RegenerativeMedicineCongressISSCRAnnualMeetingStemCe
