資源描述：
《小眼畸形相關(guān)轉(zhuǎn)錄因子.pdf》由會員上傳分享，免費在線閱讀，更多相關(guān)內(nèi)容在行業(yè)資料-天天文庫。
1、b-White?InnovationinwhiteningWhylaunchingβ-White??–Innovation創(chuàng)新?Huge(andgrowing)marketpotential市場潛力巨大（且不斷擴張）?Firsttomarket!首次面市?Mechanismofaction:abreakthrough!作用機理：巨大突破！–Performance性能?UnipexInnovationsknowledgeinwhiteningmarket在美白市場的經(jīng)驗?FullClinicalEfficacy完整
2、的臨床測試?Biomimeticpeptide仿生肽–Safety安全?Targetedmechanismofaction靶向性作用機理?Excellentsafetyprofile極佳的安全性?Batchtobatchquality嚴格的質(zhì)量控制Agenda-Whiteningpeptide?IntroductiononWhitening,brightening,lightening(BWL)market美白、亮膚、淡膚市場簡介?InVitroassays體外測試–TGF-breceptorbindingTGF
3、-b受體結(jié)合度–Inhibitionoftheconstitutiveproductionofmelaninpathway抑制構(gòu)成性黑色素沉著通道:TRP1–TRP2–tyrosinase–Inhibitionofthetyrosinaseactivity抑制酪氨酸酶活性–Inhibitionofmelaninsynthesis抑制黑色生成–Morphologicalstudiesonmelanocytes黑素細胞形態(tài)研究?Clinicalefficacy臨床功效–Whiteningandlighteningef
4、ficacy美白亮膚功效?Tolerancestudies皮膚耐受性測試?Applications應(yīng)用?Conclusion總結(jié)Whyareweusingskinwhitening??Whiter/lighterskintone美白/亮膚–InAsia,lighterandevencomplexionisassociatedwithhighersocialstatus(wealth&education)andadarkercomplexionhasbeenassociatedwithpeoplewhoworkin
5、thefieldandaremoreexposedtothesun.在亞洲，膚色白皙均勻表示高的社會地位（財富和知識）；而暗淡的膚色往往會與體力勞動或者社會下層發(fā)生聯(lián)想。Vichy??Lightenage-spotandhyper-pigmentation淡化老年斑及色素沉著過度–InNorthAmericaandEuropeskinwhiteningisseenmoreasapartofanti-agingtreatment,tohideunwantedsignsofaginglikeagespot,unhea
6、lthylife-styleandpollutionfromtheskin在北美及歐洲，皮膚美白主要歸于抗衰老范疇，即隱藏衰老跡象，如老年斑、不健康的生活習(xí)慣及污染等在皮膚留下的印跡Focusonb-White?SkinPigmentationPigmentationisdeterminedbytheamount&typeofmelaninintheskinItcanbeinfluencedby黑色素數(shù)量及種類決定皮膚膚色:1-Geneticconstitutivepigmentation(African,Asi
7、an,Caucasian)組成性色素沉著（非洲，亞洲，白種人）2-Facultativepigmentation:UVexposureviaα-MSHactivation兼性色素沉著：UV暴曬下激發(fā)促黑因子活性SkinPigmentationActorsMainActor主導(dǎo)因素：MITF(microphtalmia-associatedtranscriptionfactor)MITF（小眼畸形相關(guān)轉(zhuǎn)錄因子）?Roleinconstitutivepigmentation:responsibleofphototyp
8、e構(gòu)成性色素沉著：負責(zé)膚色?Roleinfacultativepigmentation:regulatesskinresponsetoUV兼性色素沉著：調(diào)控由UV引起的膚色變化Ex:Representsthemaestrointheorchestra如樂隊的指揮MITFItdirectsthemusicianstoproducethemusic負責(zé)指揮樂手，創(chuàng)造樂曲Sec
