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1、·862·遼寧中醫(yī)雜志2017年第44卷第4期DOI∶10.13192/j.issn.1000-1719.2017.04.064防己黃芪湯對胰島素抵抗大鼠脂代謝紊亂的影響1234賈真,李知行,孫健,藍丹純(1.廣東藥科大學中藥學院,廣東廣州510006;2.深圳市中醫(yī)院,廣東深圳518033;3.廣東省中醫(yī)院,廣東廣州510120;4.廣州中醫(yī)藥大學,廣東廣州510405)摘要:目的:觀察防己黃芪湯對高脂飼養(yǎng)大鼠胰島素抵抗脂代謝紊亂的影響。方法:將SD大鼠隨機分為正常組和高脂飼養(yǎng)組,分別予以普通飼料和高脂飼料飼養(yǎng)。造模12周后將高脂飼養(yǎng)組隨機分為模
2、型組、西藥組(吡格列酮)、中藥組(防己黃芪湯),予以高胰島素正葡萄糖鉗夾技術(shù)檢測各組大鼠葡萄糖輸注率(GIR)。干預(yù)2周后檢測測定甘油三酯(TC)、膽固醇(TG)、低密度脂蛋白(LDL)、高密度脂蛋白(HDL)及游離脂肪酸(FFA)的含量。結(jié)果:模型組GIR、HDL明顯降低(P<0.01),TC、Tg,LDL、FFA明顯升高(P<0.01);與模型組比較,治療后中藥組GIR、HDL明顯升高(P<0.01),TC、TG,LDL、FFA明顯降低(P<0.05或P<0.01)。結(jié)論:防己黃芪湯可以提高高脂飼養(yǎng)大鼠的胰島素敏感性,改善脂質(zhì)代謝紊亂。關(guān)鍵詞:
3、防己黃芪湯;胰島素抵抗;脂代謝紊亂;游離脂肪酸中圖分類號:R285文獻標志碼:A文章編號:1000-1719(2017)04-0862-03EffectofFangjiHuangqiDecoctiononLipidMetabolismDisorderofInsulinResistanceinRatsFedwithHigh-FatDiet1234JIAZhen,LIZhixing,SUNJian,LANDanchun(1.InstituteofTraditionalChineseMedicineofGuangdongPharmaceuticalUni
4、versity,Guangzhou510006,Guangdong,China;2.ShenzhenHospitalofTraditionalChineseMedicine,Shenzhen518033,Guangdong,China;3.GuangdongProvincialHospitalofTraditionalChineseMedicine,Guangzhou510120,Guangdong,China;4.GuangzhouUniversityofChineseMedicine,Guangzhou510405,Guangdong,Chin
5、a)Abstract:Objective:TostudytheeffectofFangjiHuangqiDectiononlipidmetabolismdisorderofinsulinresistanceinratsinducedbyhigh-fatdiet.Methods:SDratswererandomlydividedintonormalgroupandhigh-fatgroup.Ratsinnormalgroupwerefedwithnormaldiet.Ratsinhigh-fatgroupwerefedwithhigh-fatdiet
6、.Twelveweekslater,ratsinhigh-fatgroupwererandomlydividedintomodelgroup,westernmedicinegroup,Chinesemedicinegroup.Hyperinsulinemiceuglycemicclamptech-niquewasusedtodetecttheglucoseinfusionrateoftheratsineachgroup.Aftertreatmentfortwoweeks,triglycerides,cholester-ol,lowdensityli
7、poprotein,highdensitylipoprotein,andfreefattyacid.Results:Comparedwiththeblankgroup,GIRandHDLsig-nificantlydecreased(P<0.01),TC,TG,LDLandFFAsignificantlyincreased(P<0.01).Comparedwiththemodelgroup,GIRandHDLsignificantlyincreased(P<0.01),TC,TG,LDLandFFAsignificantlydecreased(P<
8、0.05orP<0.01)inChinesemedicinegroupaftertreatment.Conclusion: