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1、Leukemia(白血病)謝毅（Xieyi）Dep.Hematology，HuashanHospital2021/9/51xieYi,HuaShanHospitalConceptofleukemiaDefinitionItistheresultsofthetumorproliferationofheamotopoieticstemcells.（造血干細(xì)胞）Leukemiaisamalignantblooddisorder.(notsolidtumor)2021/9/52xieYi,HuaShanHospitalHeamatopoieticstemcellreproductio
2、nHSClymphoidHSCHSCdifferentiationearlyprogenitorCFU-GEMMmyeloidHSCHeamatopoieticStemCell(HSC)istheprimarycellofHeamatopoieticsystemandimmunesystem.2021/9/53xieYi,HuaShanHospital2021/9/54xieYi,HuaShanHospitalTumorproliferationofHSCDifferentiationofHSCisblocked.Leukemiacellsarestoppedonadiffe
3、rentiationstageofHSC&lackofthenormalfunction.Proliferationisoutofcontrolandapoptosisisinhibited.Leukemiacellisclonedandaccumulatedinagreatquantity.infiltrationandmetastasis2021/9/55xieYi,HuaShanHospitalmalignantblooddisordersHSCdifferentiationisblocked.Normalbloodcellsaredecreasedandleukemi
4、acellisincreased.ThefunctionofBloodandimmunesystemareshortof.Fever，bleeding，anemia2021/9/56xieYi,HuaShanHospitalmalignantblooddisordersProliferationisoutofcontrol,apoptosisisinhibitedandleukemiacellisaccumulatedinagreatquantity.Leukostasis(白細(xì)胞淤滯)Abnormalmorphologypicturesofbloodandbonemarro
5、wLiver,spleen,lymphnods,skin,CNSareinfiltratedanddysfunctionalfrequently.2021/9/57xieYi,HuaShanHospitalAccordingtotheacutemyeloidleukemia（AML）Differentiation&M0M1M2………………..M7KindofcellblastcrisisofCML，mastcellleukemia，acuteeosinophilicleukemia，basophilic…………leukemiaacutelymphocyteleukemia（A
6、LL）L1，L2，L3T－ALL、B－ALLchronicleukemia：CML、P－LL、CLL、HCL、……leukemiathetraditionclassification(FAB)ofleukemia2021/9/58xieYi,HuaShanHospitalWHOclassification(2001)1,Acutemyeloidleukemia(AML)(1),AMLwithrecurrentcytogeneticabnormalitiesAMLwitht(8;21)(q22;q22),(AML1/ETO)AMLwitht(15;17)(q22;q12),(P
7、ML/RAR?)AMLwithinv(16)(p13;q22)ort(16;16)(p13;q22),CBF?/MYH11AMLwith11q23(MLL)abnormalities2021/9/59xieYi,HuaShanHospitalWHOclassification(2001)(2),AMLwithmultilineagedysplasiaWithpriormyelodysplasticsyndromeWithoutpriormyelodysplasticsyndrome(3),AMLandm
