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1、JournalofMedicalVirology6:259-265(1980)CoronavirusInfectionsofManAssociatedWithDiseasesOtherThantheCommonColdHelleviRiskiandTapaniHoviDepartmentofVirology,UniversityofHelsinkiAbout14,000pairedsera,frompatientswithvarioustypesofacuteinfec-tiousdiseaseswithsuspectedviralorigin,werescreenedbycompleme
2、ntfixationagainstawidesetofviralantigens,includingcoronavirusOC43.AsignificantchangeinOC43antibodieswasrecordedin33casesandaconstanthightitre,definedasatitreoccurringintherespectiveagegroupinlessthan1%ofallseraexamined,wasfoundin45cases.Onthebasisofcarefulretrospectiveanalysisofhospitalcaserecords
3、itwasconcludedthatin28caseswithanin-creaseofOC43antibodytitres,andintwowithtitredecrease,adiseasecouldbeassociatedwithanacutecoronavirusinfection.In16casesthediseasewasdominatedbyrespiratorysymptoms.Eightofthesepatients,fourchildrenandfouradults,hadpneumonia.Threeoftheeightpneumoniapatientshad,how
4、ever,anotherConcomitantinfection,too.Fourpatientshadneurologicalsymptoms,onehadsevereperimyocarditis,andinfivecasesfeverwastheonlysymptomrecorded.AmongthepatientswithastatisticallysignificanthightitreofOC43antibodies,therewere14caseswhereasuggestiveassocia-tionwithadiseasecouldbeenvisagedonthebasi
5、sofhospitalrecords.Fiveofthesepatientshadpneumonia.Theseresultssuggestthathumancoronaviruses,sofarconsideredonlyasonegroupofcausativeagentsoftheconimoncold,mayalsobeassociatedwithotherandmoreseverediseasesinallagegroups.Keywords:humancoronaviruses,viraldiseases,commoncold,pneumoniaINTRODUCTlONThec
6、oronavirusesareagroupofMA-containingagentsthathavebeenassociatedwithonlyminorrespiratoryillnessesofmanbutareknowntocauseanumberofmuchmoreseverediseasesinbothlaboratoryanddomesticanimals.Membersofthecoro-navirusgroupcauseinfectiousbronchitisinchickens,neonataldiarrheaincalves,hepatitisinmice,andenc
7、ephalomyelitisinswine,etc[McIntosh,19741.Inman,coryzaandnasaldischargehavebeenthemostprominentclinicalsymptomsassociatedwithbothnaturalandexperimentalcoronavirusinfections[Hendleyetal,1972;Higgins,1974;KayeandAcc
