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1、PotentReportThissectionprovidesinformationonworldwidepatentsrelevantaminoacids)fromacoronavlrusoranlmmunogenlcfragmenttovaccinedesignandproductionThePatentReportgivestheorderlvatwe,andhaslessthanacompleteproteinsequenceoffollowinginformationtitleofpatent,patentee,patentnumber,thesp
2、ike(S)proteinArecombinantvaccinecontainingthepublicationdateandsummaryofthepatentAnumberofpolypeptlde,DNAencodingthepolypeptlde,andamethodforpatentsmthisreportarereproducedfrom'Blotechnologyprotectingananimalagainstcoronav:rusrefectionusingtheAbstracts'withpermissionofDerwentPubhca
3、tlonsLtd,Derwentvaccine,arealsonewAnidentical124-amino-acidsegmentisHouse,14GreatQueenStreet,LondonWC2B5DF,UKfoundintheC-terminalportionofSproteinsoftransmlsslble-Telephone0713442800Fax0713442900gastroententlSvarus,dogcoronavlrusorcatcoronavlrusstratusThesequenceishighlyconservedam
4、ongeoronavlruses,andiscapableofehcltmgaprotectweimmuneresponseagainstegNewdenguevirusType-Istrain;recombinantDENIproteincatmfecuous-perltonltISvirus,catenterlc-coronavlrus,dogexpression;potentialinrecombinantvaccmeconstructmn,viruscoronav~rus,p~gtransm~sslble-gastroentent~svirus,ca
5、ttlecorona-detectionanddenguefeverdiagnosisandtherapyvirus,humancoronawrusorbirdInfectmus-bronchmsvirusUmvNatSmgapore041-94World9322440,11November1993Denguewrustype-1strataDEN1-$275/90(ECACCV92042111)isclaimedAlsoclaimedare1DEN1-S275/90inreactivatedform,naDNAmolecule(specified)enco
6、dingDEN1-S275/90,Isolatedspecificepitoperegionofthyroidperoxldase,foruseasmafragmentofaDNAmoleculeasm(n),thefragmentarecombinantvaccineinthyroidtumourorHashlmotodiseaseencodingtheC,C',PreM,M,E,NS1,NS2A,NS2B,NS3,NS4A,immunotherapyNS4BorNS5geneofDEN1-S275/90,ivaDNAmoleculeorUmvMlchlg
7、anfragmentasin(u)or(nl)manexpressmnvector,vacellWorld9323073,25November1993harbourmgtheexpressmnvector,vlapolypeptldeinisolatedformwhichistheC,C',PreM,M,E,NS1,NS2A,NS2B,NS3,AnewmethodforscreeningforthepresenceofanautoantlbodyNS4A,NS4BorNS5polypeptldeofDEN1-S275/90,vnantoathyrmdpero
8、xidase(EC11117)inasample,f
