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1、ResearchinVeterinaryScience1992,53,309-314PathogenicityofconcurrentinfectionofpigswithporcinerespiratorycoronavirusandswineinfluenzavirusI.LANZA*,I.H.BROWN,D.J.PATON,MinistryofAgriculture,FisheriesandFood,CentralVeterinaryLaboratory,NewHaw,Addlestone,SurreyKT153NBCom
2、binationsofporcinerespiratorycoronavirusrespiratorydiseaseincombinationwithother(PRCV)andeitheroftwoswineinfluenzavirusesinfluencessuchasconcurrentinfections(Pensaert(H1N1orH3N2)wereadministeredintranasally1989).andbyaerosoltosix-toeight-week-oldspecificSincebothswin
3、einfluenzavirusesandPRCVpathogen:freepigs.Theclinicalresponses,grossarecirculatingintheEuropeanpigpopulation,respiratorylesionsandgrowthperformancesofcombinedinfectionsarelikelytooccur,partic-thesepigswerestudiedandcomparedwiththoseularlyatthebeginningofthefatteningp
4、eriod,ofsingle(PRCV,H1N1orH3N2)andmock-infect-whenpigsfromdifferentoriginsaremixed.Inedanimals.PRCVinfectioncausedfever,growth1987,anH3N2swineinfluenzaviruswasisolatedretardationandlunglesions,butnorespiratoryfromafarminEnglandfollowinganoutbreaksymptoms.Infectionwit
5、hswineinfluenzavirusesofsevererespiratorydisease(Pritchardeta11987).causedrathersimilar,mildsymptomsofdisease,PRCVseroconversioncoincidedwiththeout-withH1N1infectionbeingtheleastsevere.break,buttheviruswasnotisolated.However,Combinedinfectionswithinfluenzavirusesandt
6、heinfluenzaisolateonitsownfailedtoreproducePRCVdidnotappeartoenhancethepathogenicitytheclinicaldiseasewheninoculatedintoexper-oftheseviruses.Furthermore,viruseswereisolatedimentalpigs.morefrequentlyfromtissuesandnasalswabstakenTheaimofthisstudywastoestablishwhetherfr
7、om'single'than'dual'infectedanimals,suggest-ornotaconcurrentinfectioninpigswithPRCVingapossibleinvivointerferencebetweenrepli-andeitheroftwoswineinfluenzavirusstrainscationofPRCVandswineinfluenzavirus.(H1N1orH3N2)resultedinthedevelopmentofrespiratorysymptomsandmorese
8、verePORCINErespiratorycoronavirus(PRCV)isapulmonarylesions,ascomparedtosingle'agentvariantoftransmissiblegastroenteritisvirusinfect
