冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf

冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf

ID:50642058

大小:287.20 KB

頁數(shù):3頁

時(shí)間:2020-03-16

冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf_第1頁
冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf_第2頁
冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf_第3頁
資源描述:

《冠狀病毒Coronavirusl論文-2004 Structural Organization of the Genome of SARS-Associated Coronavirus (Strain SoD) Isolated on the Territory of the.pdf》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫。

1、BulletinofExperimentalBiologyandMedicine,Vol.137,No.2,February,2004197VIRUSOLOGYStructuralOrganizationoftheGenomeofSARS-AssociatedCoronavirus(StrainSoD)IsolatedontheTerritoryoftheRussianFederationG.G.Onishchenko*,V.M.Govorun,V.I.Sergienko,T.A.Akopian,K.T.Momynaliev,V.A.Ve

2、reshchagin,V.N.Lazarev,N.T.Vasil’ev*,V.I.Markov*,V.A.Merkulov*,V.A.Maksimov*,V.A.Mel’nikov*,andYu.M.LopukhinTranslatedfromByulleten’Eksperimental’noiBiologiiiMeditsiny,Vol.137,No.2,pp.222-224,February,2004OriginalarticlesubmittedDecember10,2003CompletenucleotidecDNAsequen

3、ce(29715nucleotides)ofSARS-associatedcoronavirus(strainSoD)isolatedforthefirsttimeintheterritoryoftheRussianFederationwasdetermi-ned.PhylogeneticanalysisrevealedmaximumsimilaritybetweenstrainSoDgenomeandFrankfurt1straingenome.Threenucleotidesubstitutionsdeterminingtwoamin

4、oacidsub-stitutionsweredetected.KeyWords:SARScoronavirus;Russianstrain;genomestructureAnewcoronavirusSARS-CoVcausingatypicalpneu-quences,thisagentformedanewgroupintheCoro-monia(severeacuterespiratorysyndrome)wasiso-navirusfamily.NewfeaturesweredetectedinthelatedinMarch,20

5、03,atvariouslaboratoriesoftheorganizationofSARS-CoVgenome,whichcanbeworld.AccordingtoWHO,thisdiseasewasregisteredbiologicallysignificant:short“anchor”ofglycopro-inmorethan25countriesoftheworld,includingRus-teinS,numberandlocationofminorORF,thepre-sia.Genomestructureofmore

6、than40strainsofsenceofsinglePLPprocopy.SARS-CoVisolatedfrompatientsindifferentcountri-Theaimofthisstudywasgeneticcharacterizationeswasidentified.Virusgenomeisaplus-senseRNAofCoDofSARSvirusisolatedattheterritoryofRus-consistingof30,000nucleotides,containing14opensiafromapa

7、tientwithatypicalpneumonia.readingframes(ORF)[2],5'capstructureand3'poly(A)tail.Thegenomeorganizationistypicalofcorona-MATERIALSANDMETHODSviruses:genesencodingreplicaseandfourstructuralproteinsarearrangedinasequence5'-rep-s-env-m-n-SoDstrainculturewasisolatedfromthethroat

8、and3'withshort3'and5'untranslatedregions.SARSnoseofapatientwithsuspectedatypicalpneumonia.agentg

當(dāng)前文檔最多預(yù)覽五頁,下載文檔查看全文

此文檔下載收益歸作者所有

當(dāng)前文檔最多預(yù)覽五頁,下載文檔查看全文
溫馨提示:
1. 部分包含數(shù)學(xué)公式或PPT動(dòng)畫的文件,查看預(yù)覽時(shí)可能會(huì)顯示錯(cuò)亂或異常,文件下載后無此問題,請(qǐng)放心下載。
2. 本文檔由用戶上傳,版權(quán)歸屬用戶,天天文庫負(fù)責(zé)整理代發(fā)布。如果您對(duì)本文檔版權(quán)有爭(zhēng)議請(qǐng)及時(shí)聯(lián)系客服。
3. 下載前請(qǐng)仔細(xì)閱讀文檔內(nèi)容,確認(rèn)文檔內(nèi)容符合您的需求后進(jìn)行下載,若出現(xiàn)內(nèi)容與標(biāo)題不符可向本站投訴處理。
4. 下載文檔時(shí)可能由于網(wǎng)絡(luò)波動(dòng)等原因無法下載或下載錯(cuò)誤,付費(fèi)完成后未能成功下載的用戶請(qǐng)聯(lián)系客服處理。