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1、?FreundPublishingHouseLtd.internationalJournalofNonlinearSciencesandNumericalSimulation6(2),181-186,2005ParticularSymmetryinRNASquenceofSARSandtheOriginofSARSCoronavirusXuanXiao1'2Jin-SongYao3*,Shi-HuangShao1**,Zheng-JunLi3,Yi-ShengZhu3andZheng-DeHuang1'BioinformaticsR
2、esearchCenter,DonghuaUniversity,Shanghai200051,China2ComputerDepartment,Jing-De-ZhenCeramicInstitute,Jing-De-Zhen33300,China3DepartmentofBiomedicalEngineering,ShanghaiJiaotongUniversity,Shanghai200030,ChinaAbstractSevereacuterespiratorysyndrome(SARS)belongstoCoronavirus
3、,however,itisdramaticallydifferentfromallpreviouslyknowncoronaviruses.ApeculiarcharacterofRNAsequenceisfoundinSARS,revealingparticularsymmetryinitssequencing.ComparisonofsymmetrybetweenSARSandothercoronavirusesshowsheuristicallythatSARSCoronavirusmightcomefromtheavianin
4、fectiousbronchitisvirusorporcineepidemicdiarrheavirus.Keywords:SARSCoronavirus;recombination;particularsymmetryI.Introductioninnocuousnessorcausingslightsymptomtothehuman,butseveralmutantsthatchangedvirusTheobtainedentiregenomesequenceoftropismhappenedinsomeanimalcarrie
5、r(e.g.SARSvirusshowsthatSARSCoronaviruspalmcivets)andmadethisvirusbecomedeadly(SARS-CoV)issufficientlydifferentfromalltothehuman[5],Becausehighlyfrequencypreviouslyknownthreegroupsofcoronaviruseshomologousrecombinationoftentakesplace[1-2].Comparisonbetweenthepredictedam
6、inowhenthecoronaviruseswerereplicated[6-7].Inacidsequencesforthreewell-definedenzymaticaddition,Guanetal.foundthatthevirusproteinsandthefourmajorstructuralproteinsofsequenceishomologywithSARS-CoVonwildSARS-CoVwiththosefromrepresentativeanimalupto99.8%[8],Manyresearchers
7、coronavirusesillustratesthatSARS-CoVformssuggestedthatSARS-CoVhasadifferentadistinctgroupwithinthegenusofcoronavirusesrecombinanthistory.Forexample,coronaviruses[3].Marraetal.alsoobtainedaStavrinidesetal.reportedthatSARSvirusisinsimilarresultbasedontheanalysisofdifferen
8、tfactamosaicofmammalianandavian-likeSARS-CoVisolates[4],virusesandtherecombinationbetweentheparentsvirusesmayh
