冠狀病毒Coronavirusl論文-1999 [Advances in Veterinary Medicine] Veterinary Vaccines and Diagnostics Volume 41 __ Evaluation of risks and benefits.pdf

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1、ADVANCESINVETERINARYMEDICINE,VOL.41EvaluationofRisksandBenefitsAssociatedwithVaccinationagainstCoronavirusInfectionsinCatsFREDW.SCOTTCornellFelineHealthCenterandtheDepartmentofMicrobiologyandImmunology,CollegeofVeterinaryMedicine,CornellUniversity,Ithaca,NewYork14853I.HistoricalPerspectivesofFIPI

2、I.CurrentStatusofFIPIII.CausativeAgentofFIPIV.PathogenesisofFelineCoronavirusInfectionsV.ImmunologyofFelineCoronavirusInfectionsVI.Antibody-DependentEnhancementVII.FIPVaccineVIII.RisksofFIPVaccinationIX.BenefitsofFIPVaccinationReferencesI.HistoricalPerspectivesofFIPHistorically,felineinfectiouspe

3、ritonitis(FIP)wasfirstdescribedintheearly1960sbyDr.JeanHolzworth(1963).AtleastfourearlierreferencestoclinicalcasesincatsthatmayhavebeenFIPincluded(1)aconspicuousabdominaldistentionduetoascites,witharetrospectivediagnosisofFIP,fromtheStateVeterinarySchoolinUtrecht,seenin1912-1913andreportedin1914(

4、deGrootandHorzinek,1995;Jakob,1914);(2)aninfectiouspleuritisin1942(Bonaduce,1942);(3)asevereexudativeperitonitisofunknownetiologyreportedinEnglandin1960(Joshua,1960);and(4)acaseofchronicorganizingperitonitisin1961(SmithandJones,1961).Thefirstdetaileddescriptionofaclinicalcaseof"FIP"wasreportedbyF

5、eldmannandJortner(1964).Thename347Copyright91999byAcademicPressAllrightsofreproductioninanyformreserved.1093-975X/99$25.00348FREDW.SCOTTfelineinfectiousperitonitiswascoinedbyWolfeandGriesemerin1966,anditwasearlyrecognizedtohaveanimmunopathologiccomponent(PedersenandBoyle,1980;Jacobse-Geelsetal.,

6、1980).Antibody-dependentenhancement(ADE)wasshowntoplayapartinthepatho-genesisofthedisease(Pedersen,1983;WeissandScott,1981;Olsenetal.,1993).ThefirstvaccineforFIP,anintranasalmodifiedlivevirus(MLV)vaccine,waslicensedin1991(Gerberetal.,1990;Gerber,1995).II.CurrentStatusofFIPThecurrentstatusofFIPvar

7、iesbetweentypesofcatpopulations.Itisthemostfeareddiseasetodayinbreedingcatteries,butislesscom-monandoflessconcerninthegeneralpetpopulation(Wolf,1995;KassandDent,1995;AddieandJarrett,1995).Thereisnoeffectivetreat-mentfo