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1、BRIEFREPORTS(12–40years)atthetimeofthestudy,ie,bornbetween1965andDISTRIBUTIONOFSERUMMEASLES-NEUTRALIZING1994,whohadbeenlivinginmainlandFranceformorethan3ANTIBODIESACCORDINGTOAGEINWOMENOFyears.Subjectswereconsecutivelyrecruitedfrompatientscon-CHILDBEARINGAGEINFRANCEIN2005–2006
2、sultingorhospitalizedatpediatricsandmaternitydepartmentsofIMPACTOFROUTINEIMMUNIZATION7participatinghospitalsandforwhomaserumorbloodsampleDidierPinquier,MD,*ArnaudGagneur,MD,MarieAubert,MD,wasavailable.TheprotocolwasreviewedandapprovedbyeachOlivierBrissaud,MD,§Christe`leGrasLe
3、Guen,MD,participatinginstitutioninaccordancewiththeFrenchlawonepidemiologicstudies.Allsubjects(andtheparentsofminorsIsabelleHau-Rainsard,MD,?GeorgesPicherot,MD,18years)wererequiredtogivetheirverbalconsenttoLo?¨cDePontual,MD,#Jean-LouisStephan,MD,PhD,**participateinthestu
4、dy.Patientswithanunderlyingimmunode-andPhilippeReinert,MD,PhD??ciency,aninfectiousdisease,orhavingreceivedabloodtrans-Abstract:Measlesantibodytitersweremeasuredin210Frenchfusionwereexcluded.women.Ninety-fourpercenthadprotectivevalues(120mIU/mL).Serummeasles-neutralizingantib
5、odiesweremeasuredatGeometricmeantitersweresigni?cantlydifferent(P0.001)betweentheVirusReferenceDepartmentoftheCentreforInfectionsofwomenbornbeforeandafter1983,whenmeaslesvaccinationwastheEnglishHealthProtectionAgencybytheplaquereductionrecommended(731and1358mIU/mL,respective
6、ly).geometricmeanneutralizationreferenceassay,accordingtointernationalstan-titersin4agecohortsdecreasedsigni?cantly(P0.001)withincreas-dardoperatingprocedures.Theprotectionthresholdwasde?ned6ingbirthyear.Thesedatamayhelpidentifytheappropriateageforas120mIU/mL.infantvaccinat
7、ion.Foranalysis,subjectswereclassi?edinto2groups:womenbornbeforeandafter1983,dateoftheintroductionofmeaslesKeyWords:measlesantibody,measlesimmunity,women,vaccinationintotheFrenchimmunizationcalendar.Eachgroupwasmeaslesvaccinationfurtherdividedinto2cohortsaccordingtobirthdate:
8、adolescents(12–18yearsofage)andyoungwomen(19–22years)bornafterAccept
