冠狀病毒Coronavirusl論文-2017 Development of Different Animal Models for Middle East Respiratory Syndrome-Coronavirus (MERS-CoV) Infection.pdf

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1、66ESVPandECVPProceedings2016J.Comp.Path.2017,Vol.156,54e141DEVELOPMENTOFDIFFERENTANIMALMODELSFORENDOMETRIALLESIONSUNDERLYINGFELINEMIDDLEEASTRESPIRATORYSYNDROME-CORONAVIRUSPYOMETRAyyz(MERS-COV)INFECTIONM.A.Pires*,H.Vilhena,S.Miranda,M.TavaresPereira,yyJ.Vergara-Aler

2、t*,J.VandenBrand,W.Widagdo,F.Seixas*,A.L.Saraiva*andR.Payan-Carreira*M.Munoz~*,D.Solanes*,A.Bensaid*,B.Haagmansyand*CECAV,LaboratoriodeHistologiaeAnatomiaPatologica,UTAD,Vila,zyzJ.Segales*Real,BaixoVougaVeterinaryHospital,AguedaandVet4,Estarreja,*CentredeRecerc

3、aenSanitatAnimal(CReSAeIRTA),Spain,yDepartmentPortugalzofViroscience,ErasmusMedicalCentre,TheNetherlandsandDepartamentdeIntroduction:PyometraisanimportantuterinediseaseincatsandSanitatiAnatomiaAnimals,UniversitatAutonomadeBarcelona,Spainusuallysecondarytootheruter

4、inelesions,oftenassociatedwithcysticIntroduction:MiddleEastrespiratorysyndrome-coronavirusendometrialdisease(cysticendometrialhyperplasia/pyometracom-(MERS-CoV)emergedin2012asacausativeagentofseverepneu-plex;CEH-Pyo).However,recentevidencepointstothefactthatmoniaan

5、dmortalityinman.Furtherresearchindicatedthatanan-pyometraalsoaccompaniesfelineendometrialadenocarcinomaimalreservoirforMERS-CoVdidexist(dromedarycamels).Since(FEA).Failuretoproperlyanalyzethroughhistopathologyanypyo-otheranimalspeciessusceptibletothisviralinfection

6、cannotbemetracasemaypermitthespreadofamoreaggressiveundetectedruledout,theaimofthisworkwastotestfourdifferentspeciesneoplasia.ThisworkaimedtodrawattentiontotheneedforcarefulfortheirsusceptibilitytoMERS-CoVandpotentialasananimalhistopathologicalexaminationoftheexcis

7、edfelinegenitaltract,model.particularlywhenareasofincreasedmuralthicknessarenoted.MaterialsandMethods:Atotalof14pigs,14sheep,eighthorsesMaterialsandMethods:Weevaluatedtherecordsof271feline7(ponies)andeightllamaswereinoculatedintranasallywith10ovariohysterectomy(OVH

8、)specimensfromlaboratoryarchivesTCID50/animal.Fourpigsandfoursheepwerekilledonday2postwithinthelast7years.inoculation(pi)andfouranimalsofeachspec