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1、-12·中國實用醫(yī)刊2014年7月第41卷第13期ChineseJournalofPracticalMedicineJuly2014，~o1．41，No．13胃癌根治術(shù)中及術(shù)后早期腹腔熱低滲灌注化療82例報告陳思潮洪云峰蔡華新郭文若陳文博陳志杰黃燦華石成峰【摘要】目的探討術(shù)中即時低滲溫?zé)岣骨换熉?lián)合術(shù)后早期腹腔化療的應(yīng)用價值，并研究其應(yīng)用方法。方法將T4a、T4b期胃癌82例患者隨機分成術(shù)中即時低滲溫?zé)岣骨换熉?lián)合術(shù)后早期腹腔化療組(治療組)與未行腹腔化療組(對照組)。兩組術(shù)后3～4周全身化療，sP方案(s1+DDP)每3周1次，共6次。結(jié)果治療組2年生存率為83．7
2、8％，對照組為61．76％，兩組比較差異有統(tǒng)計學(xué)意義(P=0．001)；治療組的3年生存率為70．27％，明顯高于對照組(47．06％)，兩組比較差異有統(tǒng)計學(xué)意義(P：0．002)；治療組肝轉(zhuǎn)移的發(fā)生率為8．82％，明顯低于對照組的32．35％，兩組比較差異有統(tǒng)計學(xué)意義(P<0．01)。結(jié)論術(shù)中及術(shù)后早期腹腔溫?zé)峁嘧⒒熆商岣哌M展期胃癌生存率，減少肝轉(zhuǎn)移率，是一種安全有效的治療方法?！娟P(guān)鍵詞】胃癌；腹腔游離癌細胞；術(shù)中及術(shù)后早期腹腔熱低滲灌注化療Applicationofintraoperativehypotonicperitonealchemo-hypertherm
3、iacombinedwithearlypost-operativeintraperitonealchemotherapyfor82casesofgastriccancerCHENSi—chao，HONGYun-feng，CAIHua—xin，GUOWen-ruo，CHENWen-bo，CHENZhi-jie，HUANGCan—hua，SHICheng一ng．DepartmentofOncologicalSurgery，NananHospital，Nanan362300，China【Abstract】ObjectiveToinvestigatetheapplicatio
4、nvalueofcombinedtherapyofintraoperativehypotonicperitonealchemo—hyperthermiaandearlypostoperativeintraperitonealchemotherapyongastriccancer．MethodsEighty—twoT4aandT4bstagegastriccancerpatientswererandomlydividedintotwogroups，andpatientsinthetreatmentgroupunderwentthecombinedtherapy，ando
5、nlyperitoneallavagewithdistilledwaterwasgivenforpatientsincontrolgroup．Patientsinbothgroupsacceptedveinchemo—therapywithSPschemeafteroperation．ResultsTheoverall2-yearsurvivalrateofthetherapygroupandthecontrolgroupwas83．78％and61．76％，respectively，therewassignificantdifferencebetweenthetwo
6、groups(P=0．001)．Theoverall3-yearsurvivalrateofthetreatmentgroupwas70．27％，whichwassignificantlyhigherthanthatinthecontrolgroup(47．06％)，therewassignificantdifferencebe—tweenthetwogroups(P=0．002)．Therateoflivermetastasisintreatmentgroupwas8．82％and32．35％incontrolgroup，thedifferencewassignif
7、icant(尸<0．01)．ConclusionsThecombinedappli—cationofintraoperativehypotonicchemo—hype~hermiaandearlypostoperativelyintraperitonealchemother—apyiseffectiveforgastriccancer．Intraperitonealchemotherapycanbeusedtopreventlivermetastasisforpostoperativegastriccancerpatients．【Keywords】G
