資源描述:
《不同劑量瑞舒伐他汀對(duì)急性心肌梗死高敏c-反應(yīng)蛋白的影響》由會(huì)員上傳分享,免費(fèi)在線閱讀,更多相關(guān)內(nèi)容在學(xué)術(shù)論文-天天文庫(kù)。
1、陜西醫(yī)學(xué)雜志2013年12月第42卷第12期1631不同劑量瑞舒伐他汀對(duì)急性心肌梗死高敏C一反應(yīng)蛋白的影響陜西省銅川市礦務(wù)局中心醫(yī)院心內(nèi)科(銅川727000)任騫孫琦偉摘要目的:觀察不同劑量瑞舒伐他汀對(duì)急性心肌梗死(AMI)患者高敏C一反應(yīng)蛋白(hs—CRP)的影響。方法:選取4O例健康者為正常對(duì)照組。40例急性心肌梗死患者為心梗組,并隨機(jī)分為A組、B組各20例,在給予吸氧、抗凝、擴(kuò)張冠脈血管等治療的基礎(chǔ)上,A組口服瑞舒伐他汀lOmg/d,B紐口服瑞舒伐他汀20mg/d,服藥4周。比較治療前心梗組與對(duì)照組hs—CRP水平,A組、B組治療前后hs—CRP、血脂水平,并監(jiān)測(cè)其不良反應(yīng)。結(jié)果:
2、與正常健康人相比較,AMI患者h(yuǎn)s—CRP水平明顯升高(P<0.05),治療4周后,A組、B組hs—CRP、血脂水平均較治療前明顯降低(P均<0.05),其中B組較A組降低更明顯(P<0.05),且冠脈事件發(fā)生率降低(P<0.05)。結(jié)論:AMI患者早期使用較大劑量瑞舒伐他汀(20mg/d)能顯著降低患者h(yuǎn)s—CRP、血脂水平,減少冠脈事件。主題詞心肌梗塞/治療@瑞舒伐他汀C反應(yīng)蛋白質(zhì)【中圖分類(lèi)號(hào)1R542.2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1000—7377(2013)12—1631—02Effectsofrosuvastatinatdifferentdosageonhighsensiti
3、vityC。reactiveprotein(hs-CRP)ofacutemyocardialinfarctionDepartmentofEmergency,TongchuanMiningBureauCentralHospital(Tongchuan727000)RenQJanSunQiweiABSTRACTObjective:ToobservetheeffectsofdifferentdosesofRosuvastatinonhigh-sensitivitycreativeprotein(hs—CRP)ofpatientswithacutemyocardialinfarction(AMI
4、).Methods:Fortyhealthypeoplewereselectedascontrolgroup,and40patientswithAM1wereselectedasAMIgroup.PatientsinAMIgroupwererandomlyas—signedto2groups(AandB),with20patientsineachgroup.AllpatientsinAMIgroupweretreatedwithstandardtreatmentincludingoxygeninhalation,anticoagulation,andbloodvesseldilatati
5、on,afterwitchpatientsingroupAwereorallyadministratedwithlOmg/dofRosuvastatin,andgroupBreceived20mg/dofRosnvastatinfor4weeks.hs—CRPlevelswerecomparedbetweencontrolgroupandAMIgroupatthebaseline.Also,thebaselinelevelsofhs—CRPandbloodlipidingroupAandBwerecomparedtothoseaftertreatment.Adverseeffectswe
6、realsocollected.Results:Ascomparedtocontrolgroup,thelevelofhs—CRPinpatientswithAMIincreasedsignificantly(P<0.05).Whileafter4-week’streatment,thelevelsofhs—CRPinbothgroupAandBdecreased,aswellasbloodlipidlevel(P7、naryeventswasalsoshowndecreased(P<0.05).Conclusion:EarlyuseofhigherdosesofRosuvastatin(20mg/d)cansignificantlyreducethelevelsofhs—CRPandbloodlipid,aswellflsincidenceofcoronaryevents.KEYWORDSMyocardialinfarction/therapy