不同劑量瑞舒伐他汀對(duì)急性心肌梗死高敏c-反應(yīng)蛋白的影響

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1、陜西醫(yī)學(xué)雜志2013年12月第42卷第12期1631不同劑量瑞舒伐他汀對(duì)急性心肌梗死高敏C一反應(yīng)蛋白的影響陜西省銅川市礦務(wù)局中心醫(yī)院心內(nèi)科(銅川727000)任騫孫琦偉摘要目的：觀察不同劑量瑞舒伐他汀對(duì)急性心肌梗死(AMI)患者高敏C一反應(yīng)蛋白(hs—CRP)的影響。方法：選取4O例健康者為正常對(duì)照組。40例急性心肌梗死患者為心梗組，并隨機(jī)分為A組、B組各20例，在給予吸氧、抗凝、擴(kuò)張冠脈血管等治療的基礎(chǔ)上，A組口服瑞舒伐他汀lOmg／d，B紐口服瑞舒伐他汀20mg／d，服藥4周。比較治療前心梗組與對(duì)照組hs—CRP水平，A組、B組治療前后hs—CRP、血脂水平，并監(jiān)測(cè)其不良反應(yīng)。結(jié)果：

2、與正常健康人相比較，AMI患者h(yuǎn)s—CRP水平明顯升高(P<0．05)，治療4周后，A組、B組hs—CRP、血脂水平均較治療前明顯降低(P均<0．05)，其中B組較A組降低更明顯(P<0．05)，且冠脈事件發(fā)生率降低(P<0．05)。結(jié)論：AMI患者早期使用較大劑量瑞舒伐他汀(20mg／d)能顯著降低患者h(yuǎn)s—CRP、血脂水平，減少冠脈事件。主題詞心肌梗塞／治療@瑞舒伐他汀C反應(yīng)蛋白質(zhì)【中圖分類(lèi)號(hào)1R542．2【文獻(xiàn)標(biāo)識(shí)碼】A【文章編號(hào)】1000—7377(2013)12—1631—02Effectsofrosuvastatinatdifferentdosageonhighsensiti

3、vityC。reactiveprotein(hs-CRP)ofacutemyocardialinfarctionDepartmentofEmergency，TongchuanMiningBureauCentralHospital(Tongchuan727000)RenQJanSunQiweiABSTRACTObjective：ToobservetheeffectsofdifferentdosesofRosuvastatinonhigh-sensitivitycreativeprotein(hs—CRP)ofpatientswithacutemyocardialinfarction(AMI

4、)．Methods：Fortyhealthypeoplewereselectedascontrolgroup，and40patientswithAM1wereselectedasAMIgroup．PatientsinAMIgroupwererandomlyas—signedto2groups(AandB)，with20patientsineachgroup．AllpatientsinAMIgroupweretreatedwithstandardtreatmentincludingoxygeninhalation，anticoagulation，andbloodvesseldilatati

5、on，afterwitchpatientsingroupAwereorallyadministratedwithlOmg／dofRosuvastatin，andgroupBreceived20mg／dofRosnvastatinfor4weeks．hs—CRPlevelswerecomparedbetweencontrolgroupandAMIgroupatthebaseline．Also，thebaselinelevelsofhs—CRPandbloodlipidingroupAandBwerecomparedtothoseaftertreatment．Adverseeffectswe

6、realsocollected．Results：Ascomparedtocontrolgroup，thelevelofhs—CRPinpatientswithAMIincreasedsignificantly(P<0．05)．Whileafter4-week’streatment，thelevelsofhs—CRPinbothgroupAandBdecreased，aswellasbloodlipidlevel(P

7、naryeventswasalsoshowndecreased(P<0．05)．Conclusion：EarlyuseofhigherdosesofRosuvastatin(20mg／d)cansignificantlyreducethelevelsofhs—CRPandbloodlipid，aswellflsincidenceofcoronaryevents．KEYWORDSMyocardialinfarction／therapy