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1、2013年第29卷第6期包頭醫(yī)學院學報Vo1.29No.62013JournalofBaotouMedicalCollege補骨脂對tieR,大鼠體重、腫瘤壞死因子一0【和瘦素的影響常燕琴岳嘉藺美玲張小郁鄭天珍。李偉(1.包頭醫(yī)學院基礎學院,內(nèi)蒙古包頭014060;2.甘肅中醫(yī)學院護理學院;3.蘭州大學生理學與心理學研究所)摘要目的:觀察補骨脂水煎劑對去卵巢肥胖大鼠體重、腫瘤壞死因子一和瘦素的影響。方法:將sD雌性成年大鼠隨機分為假手術組、手術組、補骨脂組,手術組、補骨脂組均行雙側(cè)卵巢切除術制備去卵巢肥胖模型,術后55d經(jīng)股動脈取血并測定雌激素、白細胞
2、介素一6、腫瘤壞死因子一和瘦素水平。結(jié)果:55d后處死大鼠,手術組的體重、攝食量、腫瘤壞死因子一水平和瘦素水平均高于假手術組(P<0.05),補骨脂組體重、攝食量、腫瘤壞死因子一水平和瘦素水平均低于手術組(P<0.O1),手術組和補骨脂組雌激素水平均低于假手術組(P<0.叭)。結(jié)論:補骨脂水煎劑能夠降低瘦素水平和腫瘤壞死因子一d水平,抑制攝食,降低去卵巢肥胖大鼠的體重。關鍵詞補骨脂;肥胖;~Ise瘤壞死因子一Ot;瘦素EfectsofFructusPsoraleaeonWeight.LeptinandTNF一inObeseRatsCHANGYanqin
3、,YUEJia,LINMeilin,ZHANGXiaoyu,ZHENGTianzhen,LIWei(1.SchoolofBasicMedicine,BaotouMedicalCollege,Baotou014060,China;2.SchoolofNursing,GansuCollegeofTraditionalChineseMedicine;3.InstituteofPhysiologyandPsychology,LanzhouUniversity)AbstractObjective:ToobservetheeffectsofFructusPsora
4、leaewaterdecotiononweights,leptinandtumornecrosisfac·tor—alpha(TNF一01)inovariectomizedobeserats.Methods:AdultfemaleSDratswererandomlydividedintoshamoperation,operation,andFructusPsoraleaegroups.RatsinoperationandFrnctusPsoraleaegroupswereunderwentbilateralovariectomytoprepareova
5、riectomizedobesemodels.Femorala~erybloodsamplesoftheratswerecollectedtodeterminethelevelsofestrogen,interleukin一6(IL一6),leptinandTNF一僅atthe55thdaysafteroperation.Results:Theweight,food—intake,leptinandTNF一0llevelsoftheratsinoperationgroupweresignificantlyhigherthaninshamoperatio
6、ngroup.Theweight,food—intake,levelsofleptinandTNF一ofratsinFrnctusPsoraleaegroupweresignificantlylowerthaninoperationgroup.Thelevelsofes·trogenofratsinoperationandFrnctusPsoraleaegroupsweresignificantlylowerthaninshamoperationgroup.Conclusion:Frnc—tusPsoraleaewaterdecotioncouldde
7、creasethelevelsofTNF—o【andleptin,suppressfoodintake,andreducetheweightinovariectomizedobeserats.KeywordsFructusPsoraleae;Obesity;TNF一0【;Leptin中國已是一個老齡化國家,老年人的健康問題已。腎補陽、納氣、止瀉之功效?。實驗研究表明補骨脂經(jīng)凸顯,尤其是絕經(jīng)期婦女。婦女絕經(jīng)后,由于體內(nèi)雌具有雌激素樣作用J。本實驗觀察去卵巢肥胖大鼠激素的降低,對垂體的抑制作用減弱,進而下丘腦和垂的體重、腫瘤壞死因子一d(tumornecr
8、osisfactor—al—體功能亢進、植物神經(jīng)功能紊亂,致使食欲亢進,引起pha,TNF—O