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1、補(bǔ)腎宣肺方治療腎陽(yáng)虛咳嗽變異性哮喘臨床研究【摘要】目的觀察補(bǔ)腎宣肺方聯(lián)用西藥治療腎陽(yáng)虛咳嗽變異性哮喘(CVA)的療效。方法80例CVA患者隨機(jī)分為對(duì)照組和治療組，每組40例。對(duì)照組口服氨茶堿緩釋片0.1?0.2g,2次/d；酮體芬片lmg,1次/d。治療組在對(duì)照組基礎(chǔ)上予補(bǔ)腎宣肺方口服。2組均以4周為1個(gè)療程，在第5周評(píng)價(jià)療效。結(jié)果治療后2組CD8+細(xì)胞顯著升高,CD4+細(xì)胞、IgE水平則顯著降低，且治療組與對(duì)照組差異有統(tǒng)計(jì)學(xué)意義(PV0.05或P<0.01)；治療組總有效率為87.5%,顯著高于對(duì)照組的70.0%(P<0.05)；治療組臨床控制患者咳嗽平均緩解天數(shù)為
2、(11.5±4.8)d,與對(duì)照組(19.3±5?2)d比較,差異亦有統(tǒng)計(jì)學(xué)意義(P<0.05)°結(jié)論補(bǔ)腎宣肺方聯(lián)用西藥治療腎陽(yáng)虛CVA療程較短,II能改善機(jī)體免疫功能?！娟P(guān)鍵詞】咳嗽變異性哮喘;補(bǔ)腎宣肺方;CD4+；CD8+；IgEAbstract:ObjectiveToobservetheeffectofapplyingnourishingkidneyandventi1atinglungcombinedwithwesternmedicineintreatingcoughvariantasthma(CVA)patientswithkidneyyangdeficienc
3、y?MethodEightyCVApatientswithkidneyyangdeficiencywer'edividedintocontrastgroupsndtherapeuticgroup,eachgroupwith40patients?ThepatientsincontrastgroupweretreatedwithAminophyllinesustained-releasetablet,0.1?0.2g,2timesaday,aswellasKetotifentahlet,lmg,ltimeaday,p.o.Asforthetherapeuticgroup,
4、thepatientsweretreatedwithChineseherbsofnourishingkidneyandvent11atinglungbasedonthetreatmentofcontrastgroup.0necoursewas4weeksforthetwogroups,andtheevaluationwerecarriedoutinthefifthweek?ResultsAfterthetreatment,CD8+ascendedsignificantly,andCD4+andIgEdescendedsignificantlycomparedwitht
5、hepre-treatment.Thereweresignificantdifferencesbetweentwogroups(P<0.05orP<0.01).Thetotaleffectiverateandthemeanalleviativeperiodforcoughwere87?5%and(11.5±4.8)daysrespectivelyintherapeuticgroup,whilethosewere70.0%ancl(19.3±5.2)daysrespectivelyincontrastgroup(卩<0.05)?ConclusionApplyingChi
6、neseherbsofnourishingkidneyandventilatinglungcombinedwithwesternmedicineintreatingCVAwithkidneyyangdeficiencycouldal1eviatethecoughsymptom,shortentreatmentperiodandimprovetheimmunologyfunctionsignificant1y.Keywords:coughvariantasthma；nourishingkidneyandventilatinglung；CD4+；CD8+；IgE咳嗽變異性
7、哮喘(CVA)是以慢性咳嗽為主要或唯一癥狀的特殊類(lèi)型的哮喘，臨床主要表現(xiàn)為頑固性十咳或胸悶癥狀，易被誤診為反復(fù)上呼吸道感染或慢性咽炎，從而大量應(yīng)用抗生素而治療效果欠佳。近年來(lái),我們對(duì)腎陽(yáng)虛CVA患者在西藥常規(guī)治療基礎(chǔ)上給予補(bǔ)腎宣肺方治療，獲得滿意療效。現(xiàn)將結(jié)果報(bào)道如下。1臨床資料1.1診斷標(biāo)準(zhǔn)參照1997年中華醫(yī)學(xué)會(huì)呼吸系病學(xué)會(huì)“支氣管哮喘防治指南”中的標(biāo)準(zhǔn)[1]:咳嗽持續(xù)或反復(fù)發(fā)作1個(gè)月，多在夜間或清晨發(fā)作,常因相關(guān)誘因而發(fā)作，如油煙、運(yùn)動(dòng)、冷空氣、過(guò)敏原或呼吸道感染后；肺功能和胸片檢查基本正常，查體無(wú)陽(yáng)性體征；氣道高反應(yīng)試驗(yàn)陽(yáng)性；應(yīng)用抗生素、止咳
